Bristol-myers Squibb Compnay

Five Prime Therapeutics, Inc.

Lin Hui Su

Paul O Sheppard

Alan J Korman

Arvind Rajpal

Guodong Chen

Ginger Chao Rakestraw

Keith Sadoon Bahjat

Ekaterina G Deyanova

Andrew Rankin

Robert J Johnston

Luis Borges

Aaron Paul Yamniuk

Richard Y Huang

Scott Ronald Brodeur

Achal Mukundrao Pashine

Andy X Deng

Richard Yu-Cheng Huang

Xiaodi Deng

Stephen Michael Carl

Jason Robert Pinckney

Hong Shen

David A Critton

Yun Wang

Alfred Robert Langish

Akbar Nayeem

Michael Quigley

Hadia Lemar

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Antibodies binding to VISTA at acidic pH

Antibodies binding to vista at acidic pH

Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Antibodies against IL-7R alpha subunit and uses thereof

Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R&#x3b1;). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

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Somerville, MA, United States of America

Lin Hui Su