The Dupont Merck Pharmaceutical Company

Dupont Pharmaceuticals Company

Lin-Hua Zhang

Joseph Auerbach

Luigi Anzalone

Philip Ma

William Frank Degrado

Jaan A Pesti

Jianguo Yin

The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the synthesis of compounds for pharmaceuticals, especially the treatment of thrombolytic disorders, and agricultural products.

Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic

This invention provides processes for the synthesis of platelet glycoprotein IIb/IIIa inhibitors and intermediate compounds useful in said processes. The compounds afforded by this invention have the formula: ##STR1##

Processes and intermediate compounds for the preparation of platelet

This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphen yl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

Method for the synthesis of anthrapyrazolones

Intermediates for the synthesis of anthrapyrazolone anticancer agents

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Wilmington, DE, United States of America

Lin-Hua Zhang