Comentis, Inc.

Lin Hong

Makoto Inoue

Shingo Yamasaki

Hisao Hamaguchi

Ryosuke Munakata

Kiyohiro Samizu

Hiroaki Tominaga

Yasuhiro Shiina

Yasuhiro Shina

The present invention provides a hydrate of N-[(4S)-2-amino-2',2&#x2032;-dimethyldispiro[1,3-oxazole-4,4&#x2032;-chromene-3&#x2032;,3&#x2033;-oxetan]-6&#x2032;-yl]-5-chloropyridine-2-carboxamide which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by &#x3b2;-secretase activity, hydrolysis of a &#x3b2;-secretase site of a &#x3b2;-amyloid precursor protein, and/or &#x3b2;-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

Chromane compounds

The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by &#x3b2;-secretase activity, hydrolysis of a &#x3b2;-secretase site of a &#x3b2;-amyloid precursor protein, and/or &#x3b2;-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

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Edmond, OK, United States of America

Lin Hong