Cable Television Laboratories, Inc.

Nektar Therapeutics

Cable Laboratories, Inc

Nektar Therapeutics Al, Corporation

N1 Life, Inc.

Lin Cheng

Thomas Holtzman Williams

Peter Paul Smyth

Eric Winkelman

Jim O'Connor

Belal Hamzeh

Steve Arendt

Luis Alberto Campos

Michael David Bentley

Jennifer A Riggs-Sauthier

Zhensheng Jia

Tacey Viegas

Bernardo A Huberman

Mu Xu

Neel Kumar Anand

Xuan Zhao

Xiaoming Shen

Jing Wang

Michael James Roberts

Thomas E Sandholm

Richard R Goodin

Timothy A Riley

Wen Zhang

Haipeng Zhang

Junwen Zhang

Bo-Liang Deng

David R Martin

Jingjie Zhu

Franco J Duarte

Natalia Aurrecoechea

Donogh John Roger O'Mahony

Xuyuan Gu

YongQi Mu

Zhongxu Ren

Sayandev Mukherjee

Jason W Rupe

Haiying Cai

Christopher J Corcimiglia

James P O'Connor

Erik Krogh-Jespersen

Xiaoyu Zang

Anthony James Brockway

Donogh O'MAHONY

Tracey X Viegas

David Martin

Provided herein are Taxol transporter compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment or prevention of a proliferative, dermatological, or ophthalmological disease or disorder.

Taxol conjugate compounds, pharmaceutical compositions comprising the same, and methods for their use

The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.

Adenosine 2 receptor antagonists

A method for tuning a power characteristic of an optical frequency comb includes controlling a modulating light source according to a plurality of modulation parameters to generate an optical frequency comb including a plurality of optical tones. Additionally, at least one of the plurality of modulation parameters is changed until a total power of the plurality of optical tones is greater than or equal to a minimum threshold value. Furthermore, at least one of the plurality of modulation parameters are changed until respective powers of each of the plurality of optical tones are within a predetermined proximity to respective target powers of each of the plurality of optical tones.

Systems and methods for tuning a power characteristic of an optical frequency comb

A radio frequency (RF) beam transmission component having optical inputs and electrical outputs may include a wavelength selective switch (WSS) that has a plurality of optical WSS outputs. Each optical WSS output may be configured to transmit one or more wavelengths of the incoming optical signals. The RF beam transmission component may include a plurality of photodetectors (PD), each photodetector having an optical PD input coupled to one or more of said plurality of optical WSS outputs and a corresponding electrical output of a plurality of PD electrical outputs. The RF beam transmission component may further include a lens that has a plurality of electrical inputs and each electrical input may be electrically coupled to at least one of the plurality of electrical PD outputs. The lens may further have a plurality of electrical lens output ports.

Ultra-wideband wireless photonic integrated antenna system

A communication system, includes a satellite receiver in operable communication with a central server, a cellular node configured to operate within a proximity of the satellite receiver, and at least one mobile communication device configured to communicate (i) with the cellular node, (ii) within the proximity of the satellite receiver, and (iii) using a transmission signal capable of causing interference to the satellite receiver. The satellite receiver is configured to detect a repeating portion of the transmission signal and determine a potential for interference from the at least one mobile communication device based on the detected repeating portion.

Systems and methods for interference detection in shared spectrum channels

Methods of preparing monodisperse oligomer reagent compositions such as oligo(ethylene glycol) reagent compositions are described herein. The methods involve reacting a halo-terminated oligomer such as an oligo(ethylene oxide) having (m) monomers with a hydroxyl-terminated oligomer such as a hydroxyl-terminated oligo(ethylene oxide) having (n) monomers.

Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition

A method for automatic discovery of a communication network including a hub, a plurality of termination devices, and a plurality of network elements. The method includes (a) associating respective geographic information with each termination device, (b) determining a respective distance of each termination device from the hub, (c) grouping, at least partially based on diagnostic information from the communication network, two or more of the plurality of termination devices sharing a common characteristic, (d) determining a topology of the communication network, and (e) determining a respective characteristic of at least one network element of the plurality of network elements.

Systems and methods for automatic discovery of a communication network

A method of modulating a series of input digital symbols of a first modulation scheme is provided. The method is implemented by a transmitter and includes receiving a sequential series of samples of the digital symbols in a first domain of the first modulation scheme. The first domain is one of the time domain and the frequency domain. The method further includes determining a dual of the first modulation scheme. The dual has a second modulation scheme in a second domain that is different from the first domain the second domain is the other of the time domain and the frequency domain. The method further includes applying a 90 degree rotational operation to the second modulation scheme to generate a rotational modulation format, modulating the series of digital symbols with the generated rotational modulation format, and outputting the modulated series of digital symbols to a receiver.

Systems and methods for OFDM duobinary transmission

A profile optimizing method is provided for a transmission of active subcarriers over a channel to user devices. The method includes steps of (i) obtaining a symbol mapping architecture for the set of profiles, (ii) calculating, from the symbol mapping architecture, a plurality of mapping orders for the set of profiles different from the logical order, (iii) determining, from the calculated plurality of mapping orders, a particular mapping order having a higher spectral efficiency than the logical order, (iv) reordering the respective codewords of the set of profiles to correspond to the particular mapping order, (v) re-mapping the symbol mapping architecture to a number of symbols corresponding to the reordered codewords, and (vi) transmitting the symbols to the population of user devices. The symbol mapping architecture includes a codeword for each profile of the set of profiles, and maps the codewords to a different number by logical order.

Systems and methods for OFDM profile management

A resource allocation method is provided for a non-orthogonal multiple access distribution of access network users communicatively coupled to a single transport medium. The method includes steps of allocating a first frequency and time domain resource to a first user and a second frequency and time domain resource to a second user of the access network users, obtaining channel information regarding a particular communication channel of the access network for which resources are allocated, grouping the first user with the second user based on an overlap of the first frequency and time domain resource with the second frequency and time domain resource, and assigning the first user to a different power allocation resource than the second user within the frequency and time domain overlap.

Systems and methods for non-orthogonal multiple access

The present disclosure generally relates to apparatus, software and methods for managing multi-channel network traffic to alleviate congestion, improve service quality and make efficient use of channel capacity. The disclosed apparatus, software and methods alleviate congestion and improve service quality by minimizing variance within a channel and/or increase overall traffic flow by minimizing the variance between channels. One or both of these objectives can be accomplished using modern portfolio theory to optimize at least one network usage parameter based on the mean and variance of the parameter(s).

Methods for managing multi-channel network traffic

A method for comparing communication links in a communication network includes (a) obtaining first raw equalizer coefficients in a frequency domain, the first raw equalizer coefficients corresponding to a first communication link, (b) obtaining second raw equalizer coefficients in the frequency domain, the second raw equalizer coefficients corresponding to a second communication link, (c) removing time delay from the first raw equalizer coefficients to generate first corrected equalizer coefficients, (d) removing time delay from the second raw equalizer coefficients to generate second corrected equalizer coefficients, and (e) comparing the first corrected equalizer coefficients to the second corrected equalizer coefficients to determine a relationship between the first and second communication links.

Systems and methods for comparing communication links

Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of pemetrexed-based compounds. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the pemetrexed-based compound is achieved.

Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds

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Superior, CO, United States of America

Lin Cheng