The Johns Hopkins University

City University of Hong Kong

Kennedy Krieger Institute, Inc.

Lin Chen

Peter C Van Zijl

Jiadi Xu

Jianpan Huang

Kannie Wai Yan Chan

A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.

D-glucose and its analogs as tracers to assess the glucose transporter function on blood-cerebrospinal fluid barrier and the functioning of the brain lymphatic system

Growing community of inventors

Baltimore, MD, United States of America

Lin Chen