Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Shanghai Electric Wind Power Group Co., Ltd.

Liming Zhang

Qiang Li

Xin Xu

Zhen Zhang

Yunfei Li

Jian Ge

Yijin Wang

Lei Liu

Dongsheng Li

Xiaojuan Zhang

Qingyun Jiang

Xiaoer Xia

Fengying Guo

Qiang Liu

Jia Chen

Hao Yu

Jing Su

Xiaobo Zhou

Kang Sun

Jiamiao Wang

Linli Zhang

Yuyun Zhang

Qimei Wu

Chengxu Zang

Jinqian Song

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

Disclosed are a class of &#x3bc;-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The &#x3bc;-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

&#x3bc;-opioid receptor agonist and preparation method therefor and use thereof in field of medicine

The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.

Vortioxetine pamoic acid salt and crystal form thereof

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Shanghai, China

Liming Zhang