General Electric Company

Mascon, Inc.

Sabic Global Technolgoies B.v.

Liming Yu

Hongyi Zhou

Reginald Donovan Smith

Peter D Miller

Nichole Lea Wood

Brian David Polizzotti

Robert Russell Gallucci

Gary William Yeager

Wei Zhang

Christopher Fred Keimel

Anup Sood

Peter Miller

Yanshi Zhang

Wenqing Peng

Jan Henk Kamps

Daniel Steiger

Bing Zhang

Su Lu

Jeffrey Bernard Fortin

Jon Michael Malinoski

Liping Zheng

Hui Lei

Long Que

Jason William Castle

Anton Beletskii

Aaron Joseph Dulgar-Tulloch

Mingna Xiong

Yanrong Zhu

Zhiyong Wang

Mark Felipe Baptista

Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.

Systems and methods for processing complex biological materials

A medical article having neutralized sulfonic acid groups on its surface, is disclosed. The article has reduced interaction with biological fluids such as insulin, human growth hormone and human serum albumin.

Medical device using sulfonated neutralized polymers with reduced adhesion of biological fluids

The invention is a device comprising a substrate and a material provided on at least a portion of the substrate and having an exposed surface. The exposed surface of the material is non bio-adhesive. The invention further includes a non bio-adhesive material composition and a method of making a device having the same non bio-adhesive surface. The invention further provides a device having a coating of a hydrophobic material. In particular, the hydrophobic material coated portion of the device is resistant to bio-adhesion.

Non bio-adhesive polymer coating composition, articles and devices thereof

The present invention provides a fluorogenic composition for assaying complement activation that comprises a substrate for C3 convertase that is linked to a first fluorophore and a second fluorophore, wherein the fluorescence of the first and second fluorophores are mutually substantially quenched when the two fluorophores are present at a distance less than the characteristic distance for the two fluorophores. In one embodiment, the fluorescence of the first fluorophore is substantially quenched by the second fluorophore, and the second fluorophore emits heat upon quenching. The present invention also provides a method for assaying complement activation, wherein the method includes the steps of incubating a biological sample with a polymer to provide a polymeric biological sample, followed by incubating the polymeric biological sample with the fluorogenic composition, and measuring the fluorescence. The method may optionally include the step of measuring the optical properties of the biological sample prior to the incubation steps. The present invention further provides a kit for assaying complement activation that comprises the fluorogenic composition disclosed herein.

Compositions, methods, and kits for assaying complement activation

The present invention relates to methods and apparatuses for water filtration comprising contacting a water stream with a membrane comprising a polysulfone having structural units of Formula I 

Polysulfone membranes methods and apparatuses

Provided herein are techniques for screening materials for hemocompatibility. Hemocompatible materials may be advantageous when incorporated into devices that may come into direct contact with blood or other bodily fluids. Such techniques take advantage of conformational changes in fibrinogen when adsorbed onto certain materials. As a result of conformational changes, the fibrinogen has altered responsiveness to cleavage by thrombin. Accordingly, the products of thrombin cleavage of fibrinogen may be assessed to determine the hemocompatibility of a material.

Method and apparatus for determining hemocompatibility

Disclosed herein is a plasmonics platform comprising a substrate; a plurality of periodically spaced nanoholes and/or nanoparticles disposed upon the substrate; wherein the average first order of periodicity between the nanoholes and/or the nanoparticles is about 5 to about 1,000 nm; and a microelectromechanical and/or a nanoelectromechanical system in operative communication with the substrate so as to vary the average first order of periodicity between the nanoholes and/or the nanoparticles.

Dynamic plasmonics-enabled signal enhancement, a device comprising the same, and a method using the same

Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for the lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.

Compositions and methods for lipoprotein uptake assays

Siren housing

A siren housing has a dish-shaped base having a back wall adapted to be secured to as support structure. The base is configured and dimensioned to contain siren components. A post projects forwardly from the back wall. The post has a cylindrical sidewall terminating at a front rim. At least one channel circumscribes a segment of the sidewall at a location spaced rearwardly from the front rim. Entry and exit slots communicate with the channel at spaced locations along the length thereof. The entry slot leads to the front rim and the exit slot leading towards the back wall. A dish-shaped cover has a front wall. A cylindrical sleeve projects rearwardly from the front wall, the sleeve having at least one pin projecting radially inwardly therefrom. The sleeve is dimensioned for axial insertion onto the post. The pin is arranged: to enter the channel via the entry slot; and to coact with the channel in supporting the cover above the base for movement between open and closed positions; and to exit the channel via the exit slot to accommodate seating of the closed cover on the base.

Growing community of inventors

Clifton Park, NY, United States of America

Liming Yu