Pfizer Corporation

Agouron Pharmaceuticals, Inc.

Abbott Laboratories Corporation

Nicox S.a.

Pfizer Products Inc.

Liming Dong

Chuangxing Guo

Yufeng Hong

Haitao Li

Anle Yang

Joseph Timothy Marakovits

Junhu Zhang

Djamal Bouzida

Nan-Horng Lin

Francesca Benedini

Indrawan James McAlpine

Jayashree Tikhe

Stefano Biondi

Yi Yang

Valerio Chiroli

Mary Catherine Johnson

Susan Elizabeth Kephart

William Vernier

Jesus Ernest Villafranca

Wesley Kwan Mung Chong

Xinjun J Hou

Ganesh Prasanna

Fabio Nicoli

Achim Hans-Peter Krauss

Junhun Zhang

Darin Vanderpool

William Francois Vernier

Jayashree Girish Tikhe

Achim Hans-Pter Krauss

Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. 

Pyrrolopyrazoles, potent kinase inhibitors

Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Nitric oxide donating prostamides

Pyrrolopyrazole, potent kinase inhibitors

Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. 

Carbonylamino pyrrolopyrazoles, potent kinase inhibitors

The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3&prime;-(5&prime;- and/or 6&prime;-substituted) pyridyl ethers.

Substituted pyridine compounds useful for controlling chemical synaptic transmission

The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.

Compounds, compositions, and methods for stimulating neuronal growth and elongation

Growing community of inventors

San Diego, CA, United States of America

Liming Dong