American Dental Association Foundation

Ada Foundation

Limin Sun

Laurence C Chow

Shozo Takagi

Huakun Xu

A method for preparing uniquely sized nanoparticles of CaFby simultaneously spray drying a first NHF and a biocompatible salt solution and a second Ca(OH)and biocompatible salt solution to form CaFsolid particles in a soluble salt matrix wherein the salt is more soluble than CaF. The salt matrix may then be dissolved and the separate CaFnanosized particles collected for use as a dental therapeutic material. The technique is useful in the preparation of other discrete, nanoparticle sized compounds and combinations by carefully choosing the solvents and solutes of the two spray dried solutions.

Method for preparation of well-dispersed, discrete nanoparticles by spray drying techniques

Nano-particles of calcium and phosphorous compounds are made in a highly pure generally amorphous state by spray drying a weak acid solution of said compound and evaporating the liquid from the atomized spray in a heated column followed by collection of the precipitated particles. Hydroxyapatite (HA) particles formed by such apparatus and methods are examples of particle manufacture useful in bone and dental therapies. Dual nozzle spraying techniques are utilized for generally insoluble compounds.

Nanostructured bioactive materials prepared by dual nozzle spray drying techniques

Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

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Germantown, MD, United States of America

Limin Sun