Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Limin Liu

Xiquan Zhang

Ling Yang

Hongjiang Xu

Fei Liu

Shanchun Wang

Wei Shi

Yizhong Zhu

Hongmei Gu

Yanlong Liu

Song Tang

Weiwei Feng

Hongying Zhang

Xujing Tang

Bin Wang

Jinan Wang

Jianqing Zhang

Yiyan Yao

Yang Li

Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Trifluoromethyl-substituted sulfonamide as BCL-2-selective inhibitor

Growing community of inventors

Lianyungang, China

Limin Liu