General Atomics, Inc.

Nestec S.a.

Societe Des Produits Nestle S.a.

Prometheus Laboratories Inc.

Procisedx Inc.

Amcol International Corporation

Limin Liu

Sharat Singh

Phillip Kim

Xinjun Liu

Jeanne Harvey

Robert Barham

Chong-Sheng Yuan

Abhijit Datta

Bruce P Neri

Michael Hale

Ralph Spindler

Kevin Cureton

Stefan Westin

Larry Mimms

Neal K Blue

Lei Fang

Hongyu Chen

Singh Sharat

Sharant Singh

An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Assay method for the detection of VCAM-1 and alpha-2-macroglobulin in blood

The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.

Antibody-based arrays for detecting multiple signal transducers in rare circulating cells

The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

Methods for detecting truncated receptors using antibody-based arrays

Drug selection for breast cancer therapy using antibody-based arrays

The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors.

Electrochemical biosensor for direct determination of percentage of glycated hemoglobin

Antibody-based arrays for detecting multiple signal transducers in rate circulating cells

The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.

Methods for assaying percentage of glycated hemoglobin

The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.

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San Diego, CA, United States of America

Limin Liu