Other

Huawei Technologies Co., Limited

Shenzhen Institute of Geriatrics

The Second People's Hospital of Shenzhen (shenzhen Institute of Geriatrics)

Eli Lilly and Company

Limin Li

Zhengzhi Wu

Bohua Long

Zhiyue Li

Yuliang Lu

Zhanyan Liu

Wenbo Zhou

Yuanhui Zheng

Shengquan Hu

Liuyang Pu

A multi-phase buck converter circuit is provided, including a power supply, a plurality of phase buck circuits, each phase buck circuit including an input terminal, an output terminal, and a second input terminal, with input terminals of the plurality coupled to the power supply, a plurality of inductors coupled to the output terminals of the plurality of phase buck circuits, the plurality of inductors providing an output voltage at an output of the multi-phase buck converter circuit, a detection controller coupled to the output terminals of the plurality of phase buck circuits, the detection controller configured to detect a fault in the plurality of phase buck circuits, and a drive circuit coupled to the detection controller and coupled to each second input terminal of the plurality of phase buck circuits. The drive circuit is configured to detect a faulty phase buck circuit and stop driving the faulty phase buck circuit.

Multi-phase buck converter circuit, fault detection method and apparatus thereof, and storage medium

A structural analog of Cyclotheonellazole A, and a synthetic method therefor and an application method thereof are provided. A compound with a structure of formula (I) and a pharmaceutically acceptable salt thereof are provided. The formula (I) is as follows: R, R, Rand Rare independently selected form the group consisting of H, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halogen group, a hydroxyl group, an amino group, a nitro group, a cyano group, and a sulfydryl group. Based on the total synthetic route of Cyclotheonellazole A, the classical reverse synthesis analysis is utilized, the structural modification is purposefully carried out, a mother nucleus of the natural product remains unchanged, and the structural analog 1a is obtained by replacing a left side chain with a simple formylamine, thereby confirming the excellent protease inhibitory activity thereof, and having a strong application prospect in the pharmaceutical industry.

Structural analog of Cyclotheonellazole A, and synthetic method therefor and application method thereof

A preparation method of a novel natural bioactive peptide Tubulysin U includes: dissolving a compound 2 in trifluoroacetic acid, heating under reflux to prepare an intermediate, reacting with a compound 3 and N,N-diisopropylethylamine to obtain a product, reacting the product with 2, 6-dimethylpyridine and tert-butyldimethylsilyl trifluoromethanesulfonate, adding sodium hydroxide after the reaction to prepare an intermediate acid, reacting the intermediate acid with a compound 6, HATU and N,N-diisopropylethylamine to obtain a product, adding triphenylphosphine to prepare an intermediate amine, adding a compound 8 and HATU to react, adding ammonium fluoride to prepare a first intermediate, adding sodium hydroxide to the first intermediate to prepare a second intermediate, adding acetic anhydride to the second intermediate to prepare a third intermediate, adding trifluoroacetic acid to the third intermediate to prepare a fourth intermediate, and adding formaldehyde and sodium cyanoborohydride to the fourth intermediate to react, thereby obtaining a target product.

Method for preparing natural bioactive peptide Tubulysin U

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Shenzhen, China

Limin Li