Life Technologies Corporation

Applied Biosystems, LLC

Life Technologies As

Other

Pe Corporation

Apptera Corporation

Lily Lu

Linda G Lee

Ronald J Graham

William E Werner

Elana Swartzman

Steven Menchen

Prasanna Krishnan Thwar

Alfred Lui

Wolfgang Hinz

Geir Fonnum

Astrid Evenroed Molteberg

Synne Larsen

Guobing Xiang

Allen Wong

Jeffrey Frediani

Pontus Lundberg

Lene Husaboe

Elisabeth Breivold

M Talha Gokmen

Talha M Gokmen

Steven M Menchen

A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.

Substrates and methods useful in sequencing

A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.

Polymer substrates formed from carboxy functional acrylamide

The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.

Water-soluble rhodamine dyes conjugates

Water-soluble rhodamine dye conjugates

Water-soluble rhodamine dye peptide conjugates

Water-soluble rhodamine dyes and conjugates thereof

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Foster City, CA, United States of America

Lily Lu