Cerus Corporation

Steritech, Inc.

Other

Hri Research, Inc.

Baxter International Inc.

Lily Lin

Laurence Corash

George D Cimino

Stephen T Isaacs

Jean Marc Payrat

Lawrence Corash

John E Hearst

Yu S Zhu

Marc Payrat

John Tessman

Carl V Hanson

Synthetic platelet storage media is disclosed for use with blood preparations intended for in vivo use. The synthetic platelet storage media is prepared by providing sodium chloride, sodium citrate, sodium acetate and sodium phosphate, and formulating in water 45-120 mM sodium chloride, 5-15 mM sodium citrate, 20-40 mM sodium acetate and 20-30 mM sodium phosphate.

Synthetic platelet storage media formulation

Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets.

Synthetic media for blood components

Methods of photodecontamination are described which employ phosphate buffered aqueous solutions. Blood products comprising plasma are diluted with these solutions and treated with psoralen.

Methods of photodecontamination using synthetic media

Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including essentially magnesium free synthetic media formulations to be employed in conjunction with the photodecontamination of platelets.

Methods are disclosed for photodecontamination to inactivate microorganisms in platelet preparations and for removal of psoralen after photodecontamination. Removal is achieved by contacting the psoralen with a psoralen-binding polymer.

Proralen inactivation of microorganisms and psoralen removal

The present invention provides an improved method for the preparation of ribonucleic acid (RNA) samples. This method utilizes heat and guanidinium thiocyanate treatment of samples followed by alcohol precipitation and centrifugation to prepare RNA samples with a high degree of sensitivity, reliability, and ease of use. Importantly, the prevent invention provides a method in which RNA samples may be prepared so as to conserve RNA preservation and precipitation reagents and time. The samples so prepared are readily amplifiable and may be used for other purposes as well.

Nucleic acid preparation methods

The present invention provides a much simplified method for the preparation of nucleic acid samples. This method provides many advantages over prior sample preparation methods in terms of greater sensitivity, reliability and ease of use. Importantly, the present invention provides a method in which nucleic acid samples may be prepared so as to conserve reagents and time. The samples so prepared are readily amplifiable and may be used for other purposes as well.

Intravenous administration of 8-methoxypsoralen is disclosed, and more specifically intravenous administration of 8-methoxypsoralen-blood preparations, including platelets. Random donor platelet bags are treated, stored and pooled prior to transfusion.

Intravenous administration of psoralen

A quality control assay to verify adequate treatment of blood product following decontamination with furocoumarins and light. The methods involve measuring the inhibition of template-dependent enzymatic synthesis of nucleic acid following the addition of compounds that add covalently to nucleic acid.

Quality control assay for platelet decontamination

Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Compositions of synthetic media are described which optimize conditions for inactivation of contaminants in blood cell preparations, using 8-methoxypsoralen, prior to long term storage and transfusion.

Synthetic media compositions and methods for inactivating bacteria and

Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets using 8-methoxypsoralen.

Synthetic media compositions for inactivating bacteria and viruses in

Methods for measuring pathogen inactivation, and in particular, methods for measuring pathogen inactivation in blood and blood products after photochemical decontamination. The methods involve measuring the inhibition of template-dependent enzymatic synthesis of nucleic acid following the addition of compounds that add covalently to nucleic acid.

Methods for measuring the inactivation of pathogens

Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated using 8-methoxypsoralen prior to long term storage and transfusion.

Methods for inactivating bacteria in blood preparations with

Methods and compounds for the preparation of nucleic acid samples. Polymerase inhibitors are treated so as to allow for amplification of nucleic acid from biological sources, including whole blood.

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Berkeley, CA, United States of America

Lily Lin