Codexis, Inc.

Lillian Jasmine Miller

Oscar Alvizo

Margie Tabuga Borra-Garske

Aksiniya Lyubenova Petkova

Agustina Rodriguez-Granillo

Anna Fryszkowska

Grant S Murphy

Joshua N Kolev

Jesse B Slaton

Nandhitha Subramanian

The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Polynucleotides encoding engineered acetate kinase variant enzymes

Cyclic GMP-AMP synthase (cGAS) enzymes have been engineered to produce polypeptides having increased cGAS activity in the cyclization of modified nucleoside triphosphates, including thiolated or fluorinated nucleoside triphosphates, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing cGAS enzymes, compositions comprising the cGAS enzymes, and methods of using the engineered cGAS enzymes are useful for the production of pharmaceutical compounds.

Engineered cyclic GMP-AMP synthase (cGAS) variant enzymes

The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered pantothenate kinase variant enzymes

Engineered acetate kinase variant enzymes

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Saratoga, CA, United States of America

Lillian Jasmine Miller