Evrys Bio, LLC

Other

Kadmon Cororation, LLC

Lillian Chiang

Qun Sun

Stacy W Remiszewski

Emre Koyuncu

Frank Kayser

Sarah Jocelyn Fink

Eain Anthony Murphy

Samuel D Waksal

Tage Honore

Novel thiazole- and isoquinoline-containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-spectrum viral infections are also presented. These compounds have shown inhibition of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

Broad spectrum antiviral compositions and methods

Novel compounds useful for treating and/or preventing HCMV infections are provided.

Anti-HCMV compositions and methods

This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.

The present invention provides a method of treating breast cancer that is nonresponsive to treatment with trastuzumab, comprising administering to a subject in need of such treatment a therapeutically effective amount of compound N-(3,4-dichloro-2-fluorophenyl)-7-({[(3aR,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methyl}oxy)-6-(methyloxy)quinazolin-4-amine, or a pharmaceutically acceptable salt thereof.

Methods for treatment of breast cancer nonresponsive to trastuzumab

Embodiments of the invention relate to the treatment of neuropathic pain in mammals. Embodiments of the invention include methods for treating neuropathic pain with benzimidazole derivatives with PPARgamma agonist activity, as well as methods for preparing medicaments used in such treatments of mammalian pain.

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Princeton, NJ, United States of America

Lillian Chiang