Richter Gedeon Vegyeszeti Gyar Rt

Lilla Forgacs

Laszlo Szporny

Bela Kiss

Egon Karpati

Gyorgy Hajos

Gyorgy Fekete

Zsolt Szombathelyi

Katalin Csomor

Arpad Kiraly

Csaba Kuthi

Csaba Szantay

Erzsebet Lapis

Istvan Laszlovszky

Aniko Gere

Sandor Holly

Jozsef Toth

Anna Boor Nee Mezei

Bulcsu Herenyi

Csaba Molnar

Jozsef Szunyog

Kristina Szekely

Lajos Szabo

Gyorgy Kalaus

Tibor Keve

Bela Stefko

Janos Kreidl

Laszlo Czibula

Janos Galambos

Bela Zsadon

Maria Farkas Nee Kirjak

Gyorgy Visky

Maria Zajer Nee Balazs

Maria Incze

Ferenc Soti

Zsuzsanna Balogh Nee Kardos

Gyongyver Soos

Margit Barta Nee Bukovecz

Tibor Frank

Zsuzsanna Szegvari

Bela Bozoky

Gabor Tigyi

The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen, hydroxyl or trifluoroacetoxy group;

Novel steroid diols, pharmaceutical compositions containing them and

The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group;

Novel steroid derivatives, pharmaceutical compositions containing them

A method of treating demyelinization clinical patterns of autoimmune origin, particularly multiple sclerosis. The pharmaceutical composition makes use of ethyl (+)-apovincaminate as the active ingredient.

Method and pharmaceutical composition for treating leukoencephalitic

The invention relates to new racemic and optically active 1,12b-disubstituted octahydroindolo[2,3-a]quinolizine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent hydrogen, halogen, nitro, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or hydroxyl,

1,12-disubstituted octahydroindolo[2,3-]quinolizine derivatives,

The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) ##STR1## or (Ib), ##STR2## wherein R.sub.1 stands for a C.sub.1-4 alkyl group; and

Eburnamenine derivatives, pharmaceutical compositions and methods

The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2, 3,4,6,7,12,12b.alpha.-octa-hydroindolo[2,3-a] quinolizine of the formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.

(-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,

The invention relates to new apovincaminol derivatives of the formula /I/ ##STR1## wherein R.sub.1 is hydrogen, nitro or halogen,

Apovincaminol derivative

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