Richter Gedeon Vegyeszeti Gyar Rt

Lilla Forgach

Egon Karpati

Laszlo Szporny

Arpad Kiraly

Bela Rosdy

Gyongyver Kiraly Nee Soos

Maria Zajer Nee Balazs

Eva Palosi

Csaba Szantay

Gyorgy Hajos

Lajos Szabo

Gyorgy Kalaus

Tibor Keve

Elemer Ezer

Gyorgy Fekete

Janos Galambos

Csaba Lorincz

Bela Zsadon

Eszter Cholnoky

Katalin Gidai

Gyozo Hortobagyi

Laszio Szporny

Mari Zajer Nee Balazs

Zsuzsanna Gyulai

The invention relates to new polycyclic compounds substituted on the A-ring. More particularly, the invention concerns new polycyclic compounds of the formula (I) ##STR1## wherein R.sup.1 is methoxy or halogen and

Polycyclic compounds substituted on the A-ring, pharmaceutical

The invention relates to the new apovincaminol-3',4',5'-trimethoxy-benzoate and acid addition salts thereof. The new compound may be prepared by reacting apovincaminol or an acid addition salt thereof with 3,4,5-trimethoxy benzoic acid or a reactive derivative thereof capable of acylation and if desired converting the compound thus obtained into an acid addition salt. The new compound of the present invention can be used in therapy in the treatment of skin diseases attached to pathological cell proliferation and in the propylaxis of such diseases.

Apovincaminol derivative and compositions and methods utilizing it for

The invention relates to the new 17,18-dehydro-apovincaminol-3',4',5'-trimethoxy-benzoate of formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of these new compounds. Still another aspect of the invention is a pharmaceutical composition for treating psoriasis.

Polycyclic compounds containing a double bond in the D-ring

The present invention relates to the compounds of the Formulae 1a and 1b and pharmaceutically acceptable acid addition salts thereof. The new 9-nitro-apovincaminol-3',4',5'-trimethoxybenzoate of the Formula 1a ##STR1## and the 11-nitro-apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 1b ##STR2## and pharmaceutically acceptable acid addition salts thereof can be prepared by nitrating the apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 11, ##STR3## if desired separating the mixture of the compounds of the Formulae 1a and 1b thus obtained into its components, if desired converting a compound of the Formula 1a or 1b thus obtained into pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention can be used in therapy in the treatment of psoriasis.

Nitro-substituted polycyclic derivatives useful in the treatment of

Skin diseases such as psoriasis in a human patient can be treated by topically or parenterally administering a dermatological composition containing a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen and

Method of treating psoriasis

Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of indomethacin by using it in a composition of 1 part of indomethacin to 7.5 to 25 parts, preferably 10 parts by weight of a salicylate. Indomethacin is the most potent ulcerating compound among approved non-steroid antiinflammatory agents.

Treating mammalian subject sensitive to indomethacin ulcerogenisis

Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of phenylbutazone by using it in a composition of 1 part of antiphlogistic to 0.2 to 50 parts by weight of alkali metal salicylate.

Antiphlogistic composition of phenylbutozone and alkali salicylate and

Growing community of inventors

Budapest, Hungary

Lilla Forgach