Vertex Pharmaceuticals, Inc.

Vertex Pharmaceuticals (canada) Incorporated

Viro Chem Pharma, Inc.

Liliane Halab

Laval Chan Chun Kong

Carl Poisson

Oswy Z Pereira

Nghe Nguyen-Ba

Sanjoy Kumar Das

Melanie Proulx

Thumkunta Jagadeeswar Reddy

Christophe Moinet

Marc Courchesne

Bettina Hamelin

Nathalie Chauret

Zhang Ming-Qiang

Bingcan Liu

Caroline Cadilhac

Monica Bubenik

Mingqiang Zhang

Paul Nguyen-Ba

Thunkunta Jagadeeswar Reddy

Nathalie Turcotte

Ming Qiang Zhang

Mélanie Proulx

Ming-Qiang Zhang

Compounds represented by formula: Wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in a host.

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The invention relates to 21-keto triterpene compounds of formula (I): wherein R, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

C-21-keto lupane derivatives preparation and use thereof

Compounds represented by formula: wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in a host.

Compounds and methods for the treatment or prevention of flavivirus infections

The invention relates to 21-keto triterpene compounds of formula (I): wherein R, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment. 

Lupane derivatives useful for treating HIV

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Outremont, Canada

Liliane Halab