Chinese Academy of Sciences

Shenzhen Institutes of Advanced Technology

Greenvalley Braintech (shenzhen) Medical Technology Co., Ltd.

Lili Niu

Hairong Zheng

Long Meng

Wei Wei

Xiaowei Huang

Zhengrong Lin

Ming Qian

Kaiyue Wang

Yang Xiao

Yongchuan Li

Congzhi Wang

Fei Li

Hui Zhou

Chen Wang

Min Su

Fei Yan

Feiyan Cai

Weibao Qiu

Yingjian Cui

Benxian Peng

Farooq Umar

Junjie Zou

Jiqing Huang

Ruibiao Guo

Zhiting Deng

Chaowei Xu

Liufeng Geng

Chengxiang Zhang

The present invention discloses a real-time ultrasonic stimulation electric signal recording chip and a preparation method thereof, where the preparation method includes the following steps: Smanufacturing an interdigital electrode on a piezoelectric substrate to obtain a surface acoustic wave chip, and manufacturing a recording electrode and an electrode lead; S, manufacturing an insulation protection layer on the chip obtained in the S, and processing the insulation protection layer to form the recording electrode, so as to obtain a chip combining the interdigital electrode and the recording electrode; S, preparing a PDMS cavity; and S, bonding the PDMS cavity prepared in the Sand the chip obtained in the S. In the present invention, combining the interdigital electrode generating a surface acoustic wave ultrasound with a multi-channel recording electrode, such that real-time recording of a multi-channel electric signal under ultrasonic stimulation is achieved.

Real-time ultrasonic stimulation electric signal recording chip and preparation method thereof

The present application provides an ultrasonic wake-up system. The system includes an ultrasonic imaging device, an ultrasound stimulation device, and an ultrasound stimulation effect evaluation device, and acquires an ultrasonic image of a target object through the ultrasonic imaging device, transmits an ultrasound to the target object based on the ultrasonic image through the ultrasound stimulation device, and adjusts the transmitted ultrasound required through the ultrasound stimulation effect evaluation device. Therefore, peripheral nerves are accurately stimulated, an uplink reticular wake-up system is activated, so as to wake up patients with disorders of consciousness.

Ultrasonic wake-up system

Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.

Conscious animal ultrasonic neural regulation device

Provided are a microfluidic apparatus, a method and system for introducing a substance into a cell. The microfluidic apparatus includes a cavity channel, a bulk wave generating device and a surface acoustic wave generating device; a microstructure is arranged on an inner wall of the cavity channel, and the microstructure is constructed for forming a bubble by a solution at the microstructure when the solution is injected into the cavity channel; the bulk wave generating device is configured to generate a bulk wave, the bulk wave enables the bubble to resonate for generating a flow field; and the surface acoustic wave generating device is configured to generate a surface acoustic wave and control a position of at least one particle in the solution.

Microfluidic apparatus, and system and method for introducing substance into cell

A method and a device for acquiring biomechanical parameters based on an ultrasonic elastomyogram are provided, wherein the method includes: synchronously collecting a dynamic myodynamics image sequence and a dynamic elasticity image sequence of a single skeletal muscle under continuous stretching; acquiring a myodynamics parameter corresponding to each myodynamics image in the dynamic myodynamics image sequence and an elasticity modulus value corresponding to each elasticity image in the dynamic elasticity image sequence respectively; and generating an ultrasonic elastomyogram curve with the myodynamics parameter as the abscissa and the synchronized elasticity modulus value as the ordinate, and estimating a muscle biomechanical parameter based on the ultrasonic elastomyogram curve. Dynamically changing biomechanical parameters can be obtained, and the obtained muscle biomechanical parameters have relatively high accuracy.

Method and device for acquiring biomechanical parameters based on ultrasonic elastomyogram

A microfluidic chip (), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (), and an electrode layer () and a functional layer () sequentially formed on the substrate (), said electrode layer () comprising a plurality of electrode groups () arranged in an array, the electrode groups () being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (); and the functional layer () being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group () and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group ().

Microfluidic chip, apparatus, system, and control and preparation method therefor

An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3D digital model according to the image data; creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region. By the use of different ultrasound transmitting sequences, ultrasound neuromodulation can be realized, and research on an action mechanism for the ultrasound neuromodulation can be performed.

Ultrasound deep brain stimulation method and system

Disclosed is an ultrasonic wave generation device for hearing recovery treatment, including an ultrasonic wave generation part. The ultrasonic wave generation part comprises a reference time-delay determination module, an emission sequence parameter determination module and an ultrasonic transducer module. The ultrasonic transducer module is used for emitting actual ultrasonic waves, and the efficiency and precision are improved by focusing by means of a plurality of array elements.

Ultrasonic wave generation device for hearing recovery treatment

Disclosed is a microfluidic system based on an artificially structured acoustic field, comprising a microcavity used to accommodate a solution containing particles and a ultrasonic emission device used to emit ultrasound, and further comprising a phononic crystal plate placed in the microcavity. The phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles. Also disclosed is a method of controlling microfluid particles based on an artificially structured acoustic field. In the particular embodiments, since a microcavity, an ultrasonic emission device and a phononic crystal plate are comprised, the ultrasonic emission device is used to emit ultrasound, and the phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles.

Microfluidic system and method of controlling particles based on artificially structured acoustic field

The present disclosure proposes an image-based method for measuring elasticity of biological tissues including following steps: obtaining N successive grayscale images of a testing biological tissue, where N is a positive integer; obtaining regions of interest (ROI) of the grayscale images; dividing the regions of interest into a grid of small sections; calculating relative displacement vector of each interrogation window using texture matching method; and calculating elastic modulus of each interrogation window according to the relative displacement vectors. The present disclosure also proposes an image-based system for measuring elasticity of biological tissues. The present disclosure applies to various resolutions of grayscale images obtaining in ultrasound imaging, optical imaging, photoacoustic imaging, CT imaging, magnetic resonance imaging ect. The system can be integrated into a traditional clinical imaging system as an image post-processing software module to characterize tissue elasticity. Because it's no need to update the traditional clinical imaging system hardware, updating cost is low. It's easy to be accepted by hospital and is convenient to popularize.

Image-based method for measuring elasticity of biological tissues and system thereof

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Shenzhen, China

Lili Niu