Ocean University of China

Qingdao Bolin Biological Technology Co., Ltd.

Lili Guo

Lihua Ma

Yongda Zhao

Baoqin Han

Jishang Sun

Lan Guo

Jing Chang

Cuiyao Li

Embodiments of the present disclosure provide an injectable photothermal hydrogel based on melanin and a preparation method and an application thereof. The injectable photothermal hydrogel is a hydroxypropyl chitosan/bis-amino polyethylene glycol modified melanin nanoparticles (HPCS/MP) hydrogel. The HPCS/MP hydrogel is prepared by mixing bis-amino polyethylene glycol modified melanin nanoparticles (MP) with hydroxypropyl chitosan (HPCS). The MP is synthesized by an amidation reaction of the melanin and the bis-amino PEG. A ratio of a volume of an MP solution to a volume of an HPCS solution in the HPCS/MP hydrogel is 4:6. A concentration of the MP solution is 20 wt %. A concentration of the HPCS solution is 4 wt %.

Injectable photothermal hydrogel based on melanin, preparation method, and application thereof

The present disclosure belongs to the technical field of veterinary biological products, and specifically relates to a triple vaccine for diseases caused byand. In the triple vaccine, antigens are an inactivatedS01 strain, an inactivatedR01 strain and an inactivatedE01 strain. The three strains used in the vaccine have high virulence, disable immunogenicity and disable cross-protection. The prepared vaccine has a desirable safety, causing no local or systemic adverse reactions. In a shelf life test, all indicators of the vaccine are stable and effective after a data analysis of traits, a safety test and an efficacy test; in addition, efficacy test results prove that the inactivated triple vaccine can produce desirable antibodies and relatively desirable attacking protection.

Triple vaccine for diseases caused byand

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Qingdao, China

Lili Guo