Teva Pharmaceutical Industries Limited

Lilach Hedvati

Claude Singer

Gideon Pilarski

Ziv Dee-Noor

Gideon Pilarsky

Yuriy Raizi

Sharon Tomer

Judith Aronhime

Sigalit Levi

Sharon Avhar-Maydan

Adi Yeori

Eyal Gilboa

Ana Kwokal

Revital Burstein

Rinat Moshkovits-Kaptsan

Ziv Dee Noor

The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium.

Raltegravir salts and crystalline forms thereof

Processes for preparing and purifying Pregabalin and salts thereof are provided.

Method for the preparation of Pregabalin and salts thereof

The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.

Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid

The invention relates to pure (R)&#x2014;CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)&#x2014;CMH and to the process for isolating (S)&#x2014;CMH from the mother liquor.

The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM-Cl, and OLM-eliminate.

Olmesartan medoxomil with reduced levels of impurities

The present invention provides a process for preparing olmesartan medoxomil.

Preparation of olmesartan medoxomil

The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with C-alcohol; and combining the organic phase with an organic base.

Pregabalin free of lactam and a process for preparation thereof

A Pregabalin having a low level of 3-isobutylglutaric acid is provided.

Pregabalin free of isobutylglutaric acid and a process for preparation thereof

Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.

Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof

Crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.8, 18.4, 19.2, 20.7, and 23.7&#xb0; 2&#x3b8;&#xb1;0.2&#xb0; 2&#x3b8;, methods for its preparation, its pharmaceutical compositions thereof, and methods for the preparation of crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.7, 15.4, 17.2, 18.2, and 23.0&#xb0; 2&#x3b8;&#xb1;0.2&#xb0; 2&#x3b8;, are provided.

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Doar Na Hefer, Israel

Lilach Hedvati