Guangzhou Henovcom Bioscience Co. Ltd

Lijun Zhang

Jiancun Zhang

Deyao Li

Yiqian Zhou

Qi Guo

Jufu Zhang

Kun Wang

Yang Hu

Xiaoxi He

Qingan Zou

Huajin You

Chen Guo

Wanjun Tang

Yanwei Chen

Huixuan Chen

Jiafeng Chen

Suyong Li

Yanhui Liu

Ning Kang

Feng Wu

A novel tetrahydronaphthalene compound is provided, or a stereoisomer, a solvate, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition including the compound, and a use of the compound or the composition for preparing a medicament in prevention and/or treatment of a central nervous system disease, wherein the compound has a structure of formula (I), wherein each of X, Y, Z, W and R is defined as described in the present disclosure.

Tetrahydronaphthalene compounds, pharmaceutical compositions, and uses thereof

The present disclosure relates to compounds for RNA capping and uses thereof, which belong to the technical field of genetic engineering. Compounds of formula I can result in high levels of capping efficiency, and the capped mRNA exhibits a high transcription level and increased expression.

Compounds for RNA capping and uses thereof

Provided are novel heteroaromatic compound as an Autotaxin inhibitor, a pharmaceutical composition comprising the compound, and a use thereof in a treatment of a disease with a pathological feature of Autotaxin overexpression in a mammal, wherein the compound is according to formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof; wherein each of R, Ar, Ar, Ar, W, Y, Z, and Cy is defined in the present disclosure.

Aromatic heterocyclic compound, and pharmaceutical composition and use thereof

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Guangzhou, China

Lijun Zhang