Shenzhen Chipscreen Biosciences Co., Ltd.

Gcp Applied Technologies Inc.

Lijun Xin

You Zhou

Zhibin Li

Xianping Lu

Robert A Wiercinski

Hongmei Ding

Chao Fu

Qianjiao Yang

Huhe Chen

Yonglian Song

Yanan Wang

Yu Zhang

Song Shan

Zhiqiang Ning

Xiaoliang Wang

Jindi Yu

Jiangfei Zhu

Desi Pan

Shigang Wang

Qi Wei

Huiyun Huang

The invention provides a waterproofing membrane which does not require a removable release sheet but which nevertheless bonds to post-cast concrete and facilitates water-tight sealing at membrane-to-membrane overlaps. The waterproofing membrane comprises a carrier and pressure-sensitive adhesive (PSA) layers, an inorganic particle layer having particulate bodies which are partially embedded in the PSA and which have an average particle size less than the average thickness of the PSA layer, and an anti-submarining nano-silica-containing coating layer attached to un-embedded portions of the inorganic particles to prevent total embedding into the PSA when the membrane is rolled or unrolled, whereby water-tight seams are facilitated between overlapped portions of adjacently installed waterproofing membranes, and whereby the water-tight seam is achieved preferably using only detailing or waterproofing tape and without the additional use of a liquid primer, mastic, or other coating.

Facilitated detailing for pre-applied waterproofing membranes

A biphenyl compound represented by formula (I), a preparation method therefor and an application thereof. The present invention also relates to a pharmaceutical composition that comprises the compound as an active ingredient. The compound is a novel small molecule immunomodulator having excellent oral absorption features and can be used for treating and/or preventing various immunity-related diseases.

Biphenyl compound as immunomodulator, preparation method therefor and application thereof

The present invention relates to a urea compound and a preparation method and an application thereof. The structure of the present compound is represented by formula (I), the definition of each variable in the formula being as described in the description. The compound can block interaction between the PD-1/PD-L1 signalling pathways. The compound of the present invention can be used for treating or preventing diseases related to the signalling pathways, such as cancer, autoimmune disease, chronic infectious disease, and other diseases. 

Urea compound and preparation method and application thereof

The invention discloses a type of fused imidazole compound, preparation method and application thereof. The structure of the compound is shown in general formula I. The definition of each group therein is as described in the specification. These compounds are capable of selectively inhibiting indoleamine 2,3-dioxygenase (IDO). The compounds can act as an IDO inhibitor for treating and/or preventing a disease having a pathological feature with IDO-mediated tryptophan metabolic pathways, for example, cancer, eye disease, autoimmune disease, psychological disorder, depression symptom, anxiety disorder and other diseases.

Fused imidazole compound having indoleamine 2,3-dioxygenase inhibitory activity

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Guangdong, China

Lijun Xin