Guangdong Zhongsheng Pharmaceutical Co., Ltd

Guizhou Bailing Group Pharmaceutical Co., Ltd.

Sichuan University

Guangdong Raynovent Biotech Co., Ltd.

Chengdu Zenitar Biomedical Technology Co., Ltd.

China Pharmaceutical University

Lijuan Chen

Yuquan Wei

Chaofeng Long

Xiaoxin Chen

Zhuowei Liu

Shuhui Chen

Peng Zhang

Hao Wu

Fang Liu

Zheng Wang

Lingyun Wu

Jun Lin

Changqing Wei

Yunhui Li

Haoyu Ye

Chenshi Xie

Ninghua Tan

Lihua Song

Jianhong Yang

Zhe Wang

The present invention belongs to the field of chemical medicines, and particularly relates to a 2,4-disubstituted pyrimidine derivative, a preparation method therefor and a use thereof. The present invention provides a 2,4-disubstituted pyrimidine derivative, the structural formula of which is as shown in formula I. The present invention also provides a preparation method for the 2,4-disubstituted pyrimidine derivative and a use thereof. The 2,4-disubstituted pyrimidine derivative provided by the present invention can be used as a kinase inhibitor with double functional targets of JAK2 and FLT3, or a kinase inhibitor with independent functional targets of JAK2 or FLT3, thus providing a new choice for preparing a multi-target inhibitor.

2,4-disubstituted pyrimidine derivative, preparation method therefor and use thereof

The present invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications thereof. The invention provides 4-substituted coumarin derivatives with a structural formula as shown in Formula I. The invention also provides preparation methods and applications for the above 4-substituted coumarin derivatives. The compounds provided in the invention have strong anti-tumor activity with IC50 for plural tumor cell lines between 0.01-5 nM, and it also performs better to inhibit microtubule polymerization and has diversified biological activities and low toxicity, providing new options for drug-sensitive and drug-resistant tumor cells. 

4-substituted coumarin derivatives and preparation methods and uses thereof

A compound represented by Formula I or pharmaceutically acceptable salt thereof. The present invention relates to a 4-arylamino quinazoline hydroxamic acid compound having a histone deacetylase inhibitory activity, preparation method of the compound, pharmaceutical composition comprising the compound, and use of the compound and the pharmaceutical composition in the preparation of a histone deacetylase inhibitor medicine. The present invention aims at acquiring, via a medicine design and a synthetic technology, a series of selective histone deacetylase inhibitors having good hypotype selectivity and favorable pharmacokinetic characteristics based on optimization of an enzyme surface recognition region and connection region of 4-arylamino quinazoline, thus reducing an effect on normal tissues or cells while improving an antineoplastic activity of the normal tissues or cells.  In Formula I, the variables are as described herein.

Histone deacetylase inhibitor, and preparation method and use thereof

The invention discloses a crystal form A of a compound (I) and a preparation method thereof, and further discloses an application of the crystal form A as a PDE2 or TNF-&#x3b1; inhibitor. 

Crystal form A of 7-(cyclopropylmethyl)-1-((()-4-hydroxy-4-methylcyclohexyl)methyl)-3-methyl-1H-purine-2,6-(3H,7H)-dione for treating liver diseases

The present invention relates to the field of the chemical medicines, and in particular, to purinyl-N-hydroxyl pyrimidine formamide derivatives, a preparation method therefor and a use thereof. The present invention provides a purinyl-N-hydroxyl pyrimidine formamide derivative having a structure represented by formula (I). The invention also provides a method for preparing said purinyl-N-hydroxyl pyrimidine formamide derivative and a use thereof. Purinyl-N-hydroxyl pyrimidine formamide derivative provided in the invention can be not only a PI3K and HDAC double-functional target kinase inhibitor, but also a PI3K or HDAC single target kinase inhibitor, thus providing new choice for preparing multi-target inhibitors. 

Purinyl-N-hydroxyl pyrimidine formamide derivative, preparation methods and uses thereof

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Quinoline derivatives as SMO inhibitors

The present invention relates to millepachine ((E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogs. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds. 

(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof

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Sichuan, China

Lijuan Chen