Jenkem Technologyco., Ltd.. (tianjin)

Beijing Baidu Netcom Science Technology Co., Ltd

Jenkem Technology Co., Ltd.

Lihua Xu

Xuan Zhao

Zewang Feng

Jinliang Wang

Zhen'guo Wang

Zhenguo Wang

Zhixiong Guo

Wenzhe Huang

Provided are a method and apparatus for detecting a status of a lens, an electronic device and a medium. A specific implementation includes: determining current feature points included in a current image according to the current image captured at a current moment by a to-be-detected lens of a target driving device; determining historical feature points included in a historical image according to the historical image captured at a historical moment by the to-be-detected lens; and matching the current feature points with the historical feature points and determining a status detection result of the to-be-detected lens according to a matching result. Therefore, an effect of determining a status of the to-be-detected lens of the target driving device is achieved and the problem of a potential safety hazard of the target driving device due to an abnormal status of the to-be-detected lens can be avoided.

Method and apparatus for detecting a status of a lens, electronic device and medium

Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are a PEG-naloxone conjugate of general formula (II) and a pharmaceutical composition comprising the conjugate. In the conjugate, n is an integer in the range of 1-20. Also provided is a three-branched or four-branched conjugate of PEG and naloxone. Structural modification of naloxone with a hydrophilic polymer improves the pharmacokinetic properties of the drug, increase the water solubility of naloxone, improve the in vivo distribution of the drug, reduce the side effects of naloxone on central nervous system, and relieve bowel dysfunction and constipation caused by chronic administration of opioids. Also provided are a pharmaceutical composition comprising the conjugate of the invention and use of the conjugate. 

Conjugate of polyethylene gylcol and naloxone and pharmaceutical composition and use thereof

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Beijing, China

Lihua Xu