Taipei Medical University

National Taiwan University

Fu Jen Catholic University

Uwm Research Foundation, Inc.

Medical University of Vienna

University of Belgrade—faculty of Pharmacy

Lih-Chu Chiou

James M Cook

Wei-Jan Huang

Miroslav M Savic

Werner Sieghart

Pi-Chuan Fan

Daniel Knutson

Laurin Wimmer

Hui-Ju Tseng

Su-Jane Wang

Kai-Cheng Hsu

Liang-Chieh Chen

Zdravko Varagic

David Chan Bodin Siebert

Christopher Witzigmann

Matheus Meirelles

Marko Mihovilovic

Margot Ernst

Ranjit Verma

Provided is a method for preparing hispidulin or a derivative thereof. The method includes selective protection of trihydroxybenzaldehyde, followed by regioselective iodination, selective protection, Stille coupling, Baeyer-Villiger oxidation and basic hydrolysis to obtain a protected intermediate compound. Then, alkylation, Claisen-Schmidt condensation, cyclization and deprotection of the protected intermediate compound are performed to obtain hispidulin or the derivative thereof. The present disclosure provides an efficient method for total synthesis of hispidulin or the derivative thereof with concise reaction steps and high yield.

Method for preparing hispidulin and its derivatives

The present invention relates to the use of a composition made fromfor treating tic disorder or sensorimotor gating deficits, wherein the composition is particularly made from the leaves of the plant.

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Taipei, Taiwan

Lih-Chu Chiou