Bristol-myers Squibb Compnay

Ligaya Simpkins

Lawrence G Hamann

Jeffrey A Robl

James Clifford Sutton

Yingzhi Bi

David John Augeri

Tammy C Wang

James J Li

Chong-qing Sun

Alexandra Holubec

Yan-Ting Huang

David R Magnin

Mark C Manfredi

Mark S Kirby

Ashish Khanna

There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.

Bicyclic modulators of androgen receptor function

The invention provides compounds according to formula I  Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a patient in need of therapy for an androgen receptor associated condition by administering a therapeutically effective amount of at least compound of the present invention.

[object Object]

Compounds are provided having the formula (I) Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.

Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods

Growing community of inventors

Titusville, NJ, United States of America

Ligaya Simpkins