E. R. Squibb Sons, Inc.

Ligaya M Simpkins

B Richard Vogt

Eric M Gordon

Ravi K Varma

Hydroximic acids of 7-oxabicycloheptane substituted ether and thioether prostaglandin analogs are provided having the structural formula ##STR1## wherein Y is O or ##STR2## and including all stereoisomers thereof. The compounds are inhibitors of prostaglandin and biosynthesis and as such are useful, for example, as anti-allergy and antiinflammatory agents and also as antipsoriatic agents.

Hydroximic acids of 7-oxabicycloheptane substituted ethers and

Intermediates are provided having the structure ##STR1## wherein X is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl. These intermediates are useful in preparing pyrazolo[1,5-c]quinazoline anti-allergy compounds.

5-(Optionally substituted 2-aminophenyl)-1H-pyrazole-3-methanol

Compounds are provided having the structure ##STR1## wherein R.sup.1 is carboxyl; hydroxymethyl; CO.sub.2 R.sup.3 wherein R.sup.3 is lower alkyl, Li.sup.+, Na.sup.+ or K.sup.+ ; or ##STR2## R.sup.2 is hydrogen, lower alkyl, aryl or trifluoromethyl; and X is hydrogen, lower alkyl, lower alkoxy, halogen (Cl, Br and F), or trifluoromethyl. These compounds are useful as anti-allergics.

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Ligaya M Simpkins