Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Medshine Discovery Inc.

Genfleet Therapeutics (Shanghai) Inc.

Genfleet Therapeutics Inc.

Lifang Wu

Fei Sun

Shuhui Chen

Ling Yang

Hao Wu

Charles Z Ding

Zhaozhong Ding

Jian Li

Jianyu Lu

Xiquan Zhang

Guoping Hu

Hongjiang Xu

Lihong Hu

Weidong Li

Shenyi Shi

Huijun He

Jinhua Du

Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I). 

Anti-HBVtetrahydroisoxazolo[4,3-c]pyridine compounds

Disclosed in the present invention are a crystal form and salt form of a TGF-&#x3b2;R1 inhibitor and a preparation method therefor, and further disclosed is an application of the crystal form and the salt form in preparation of medicines for treating cancers. 

Crystal form and salt form of TGF-&#x3b2;RI inhibitor and preparation method therefor

The present invention relates to a 7-(thiazol-5-yl)pyrrolopyrimidine compound as a TLR7 agonist, and particularly relates to a compound shown in formula (I), pharmaceutically acceptable salt and preparation method thereof, a pharmaceutical composition containing such a compound, and usage thereof in preparing an antiviral drug. 

7-(thiazol-5-yl) pyrrolopyrimidine compound as TLR7 agonist

The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation process thereof, a pharmaceutical composition containing such compounds and use thereof for manufacturing a medicament against viral infection. 

Pyrrolopyrimidine compounds used as TLR7 agonist

A benzotriazole-derived &#x3b1; and &#x3b2;-unsaturated amide compound used as TGF-&#x3b2;R1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I). 

Benzotriazole-derived &#x3b1; and &#x3b2;-unsaturated amide compound used as TGF-&#x3b2; RI inhibitor

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Shanghai, China

Lifang Wu