Imec

Imec Vzw

Katholieke Universiteit Leuven, Ku Leuven R&d

Katholieke Universiteit Leuven

Panasonic Corporation

Interuniversitair Microelektronica Centrum (imec)

Johns Hopkins University

Universiteit Gent

Vib Inc.

Liesbet Lagae

Peter Peumans

Pol Van Dorpe

Chengxun Liu

Tim Stakenborg

Gustaaf Regina Borghs

Willem Van Roy

Paolo Fiorini

Chengjun Huang

Kai Cheng

Chang Chen

Iwijn De Vlaminck

Wouter Eyckmans

Dries Vercruysse

Roel Wirix-Speetjens

Kris Verstreken

Wayne Hiebert

Jo De Boeck

Tatsurou Kawamura

Yasuaki Okumura

Yukari Nishiyama

Masahiko Shioi

Geert Vanmeerbeeck

Richard Stahl

Benjamin Jones

Simone Severi

Abdulkadir Yurt

Peter Bienstman

Karolien Jans

Maria Op De Beeck

Dries Braeken

Wim Annaert

Joni Dambre

Bivragh Majeed

Bert Du Bois

Andim Stassen

Philippe Helin

Ben Jones

Hilde Jans

Jorge A Bernate

German Drazer

Richard Min

Deepak Balaji Thimiri Govinda Raj

Sven Cornelissen

Bendix Schneider

Zhenxiang Luo

Shuji Sato

Ronald Kox

Deepak Balaji Thimiri Govinda Ray

The present disclosure relates to a fluid analyzing device that includes a sensing device for analyzing a fluid sample. The sensing device includes a microchip configured for sensing the fluid sample, and a closed micro-fluidic component for propagating the fluid sample to the microchip. The fluid sample can be provided to the micro-fluidic component via an inlet of the fluid analyzing device. And a vacuum compartment, which is air-tight connected to the sensing device, can create in the micro-fluidic component a suction force suitable for propagating the fluid sample through the micro-fluidic component.

Compact fluid analysis device and method to fabricate

A method for three-dimensional imaging of a sample () comprises: receiving () interference patterns () acquired using light-detecting elements (), wherein each interference pattern () is formed by scattered light from the sample () and non-scattered light from a light source (), wherein the interference patterns () are acquired using different angles between the sample () and the light source (); performing digital holographic reconstruction applying an iterative algorithm to change a three-dimensional scattering potential of the sample () to improve a difference between the received interference patterns () and predicted interference patterns based on the three-dimensional scattering potential; wherein the iterative algorithm reduces a sum of a data fidelity term and a non-differentiable regularization term and wherein the iterative algorithm includes a forward-backward splitting method alternating between forward gradient descent () on the data fidelity term and backward gradient descent () on the regularization term.

Lensfree method for imaging biological samples in three dimensions

The present disclosure relates to devices and methods for analyzing a fluid sample. An example device comprises a fluidic substrate comprising a micro-fluidic component embedded therein, for propagating a fluid sample; a needle or inlet for providing the fluid sample which is fluidically connected to the micro-fluidic component; a lid attached to the fluidic substrate thereby at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component; wherein the fluidic substrate is a glass fluidic substrate and wherein the lid is a microchip. The present disclosure also relates to a method for fabricating a fluid analysis device. The method comprises providing a fluidic substrate; providing a lid; attaching the lid to the fluidic substrate to close the fluidic substrate at least partly.

Compact glass-based fluid analysis device and method to fabricate

A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

Modulation of luminescent dyes

A micro analysis chip comprises an inlet and a fluid flow path communicating thereto. The fluid flow path comprises a first flow path, a second flow path, and a third flow path arranged continuously along a longitudinal direction of the fluid flow path. An antibody is bound on at least one peripheral surface selected from the group consisting of peripheral surfaces of the second and third flow paths. A cross-sectional area of the third flow path is constant or increased monotonically along a direction X from the second flow path toward the third flow path. A cross-sectional area of the second flow path is increased monotonically along the direction X from the one end to the other end of the second flow path. A cross-sectional area of the first flow path is larger than a cross-sectional area at the one end of the second flow path.

Micro analysis chip and fabrication method thereof

Sensor devices for quantifying luminescent targets are described herein. An example device comprises a light source for exciting the targets, thus generating luminescence signals and a detector for detecting these signals, resulting in a detected signal which comprises a desired signal originating from the targets and a background signal. It moreover comprises a bleaching device for bleaching of at least part of the sources generating the background signal and a processor configured to trigger the bleaching device to start bleaching, and to trigger the light source for exciting the remaining luminescent targets which are not bleached, and to trigger the detector for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.

Bleaching of dyes in luminescent detection

The present disclosure relates to a device for analyzing a fluid sample. In one aspect, the device includes a fluidic substrate that comprises a micro-fluidic component embedded in the fluidic substrate configured to propagate a fluid sample via capillary force through the device and a means for providing a fluid sample connected to the micro-fluidic component. The device also includes a lid attached to the fluidic substrate at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component. The fluidic substrate may be a silicon fluidic substrate and the lid may be a CMOS chip. In another aspect, embodiments of the present disclosure relate to a method for fabricating such a device, and the method may include providing a fluidic substrate, providing a lid, and attaching, through a CMOS compatible bonding process, the fluidic substrate to the lid to close the fluidic substrate at least partly.

A sensor device for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector for obtaining an at least one dimensional pattern of measured signals, wherein the detector is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.

Quantification of topologically arranged luminescent dyes

The present disclosure relates to a fluid analysis device which comprises a sensing device for analyzing a fluid sample, the sensing device comprising a micro-fluidic component for propagating the fluid sample and a microchip configured for sensing the fluid sample in the micro-fluidic component; a sealed fluid compartment containing a further fluid, the compartment being fluid-tight connected to the sensing device and adapted for providing the further fluid to the micro-fluidic component when the sealed fluid compartment is opened; and an inlet for providing the fluid sample to the micro-fluidic component. Further, the present disclosure relates to a method for sensing a fluid sample using the fluid analysis device.

Fluid analysis device

A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.

Time, space digitally resolved quantification of luminescent targets

A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.

Dynamic magnetic cell sorting

A device for extracting at least one object characteristic of an object () is presented, the device comprising: a light sensor () for recording a hologram of an object and a processing unit () coupled to the light sensor and configured for extracting at least one object characteristic from the hologram; wherein the processing unit is configured for extracting the at least one object characteristic from a section of the hologram without reconstructing an image representation of the object. Further, a device () for sorting an object (), a method for identifying an object and a method for sorting objects is presented.

Holographic device and object sorting system

The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.

Semiconductor device for detecting fluorescent particles

The present disclosure relates to microbubble generator devices for deflecting objects in a liquid, systems for sorting objects that utilize such devices, and methods for fabricating such devices. At least one embodiment relates to a micro-fluidic device for deflecting objects in a liquid. The device includes a substrate for providing an object-containing liquid thereon. The device also includes a microbubble generator that includes at least one microbubble generating element. The microbubble generator is located on a surface of the substrate and in direct contact with the object-containing liquid when the object-containing liquid is provided on the substrate. The at least one microbubble generating element is configured to deflect a single object in the object-containing liquid through generation of a plurality of microbubbles.

Microbubble generator device, systems and method to fabricate

A method () for determining a concentration of an analyte in a fluid or fluid sample, comprises: providing () a SERS substrate comprising receptor molecules () capable of binding competitor molecules (); contacting () the SERS substrate () with a fluid (sample) comprising analyte () and such competitor molecules (); radiating () the SERS substrate () with a light source while measuring a SERS signal; and determining () a concentration of the analyte () based on the measured signal level. A corresponding device and system are also provided.

Method and device for detecting analytes

Growing community of inventors

Leuven, Belgium

Liesbet Lagae