Boehringer Ingelheim Pharma Kg

Lienhard Wolter

Franz Dietrich Klingler

Franz Dietrich Klinger

Wolfgang Dietrich

An improved process for preparing adrenaline, or an addition salt thereof, on an industrial scale, with asymmetric hydrogenation as a key step and a special sequence of successive steps, using &lsqb;Rh(COD)Cl&rsqb;,as catalyst and a chiral, bidentate phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphinomethyl)-N-methylaminocarbonylpyrrolidine as the catalyst system.

Process for preparing adrenaline

The present invention relates to an improved process for preparing L-phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the key step and a special sequence of subsequent steps, using &lsqb;Rh(COD)Cl&rsqb;,as catalyst and a chiral, two-pronged phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalyst system.

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Munich, Georgia

Lienhard Wolter