Tsinghua University

Lien-Yu Hung

Gwo-Bin Lee

Chih-Hung Wang

Wen-Bin Lee

Chien-Yu Fu

An aptamer specific to ovarian cancer and a detection method for ovarian cancer are provided. The aptamer includes a following nucleotide sequence: 5'-ncaaannncnnnnanncnnnnnnnnnnngaannnannngg-3&#x2032;, wherein n is a nucleotide independently selected from 'a,' 't,' &#x201c;c,&#x201d; and &#x201c;g.&#x201d;

Aptamer specific to ovarian cancer and detection method for ovarian cancer

The present disclosure relates to an oligopeptide which is highly specific to an ovarian cancer. The oligopeptide includes an amino acid sequence of SEQ ID NO: 1. The present disclosure also relates to a test kit including the oligopeptide for detecting ovarian cancer and an ovarian cancer detection method by using the oligopeptide.

Oligopeptide specific to ovarian cancer, polynucleotide for encoding oligopeptide, test kit for detecting ovarian cancer and method for detecting ovarian cancer

The present invention provides ovarian cancer-specific aptamers, which are selected in vitro using SELEX and a microfluidic chip system. The aptamers can also bind to different histologically-classified ovarian cancer cells with high affinity accordingly. Therefore, the aptamers of the present invention and the applications thereof can not only be used in detection of ovarian cancer cells but also be applied in recognition of different histologically-classified ovarian cancer cells.

Growing community of inventors

Hsinchu, Taiwan

Lien-Yu Hung