University of California

Chinese Academy of Sciences

Lien Wang

Olivier Civelli

Yan Zhang

Zhiwei Wang

Xinmiao Liang

Xiuli Zhang

Chaoran Wang

Yanxiong Ke

A method of treating nervous system diseases associated with dopamine receptors comprising administering a patent in need a compound having a structure of general formula (I) or a pharmaceutical acceptable salt, hydrate, or solvate thereof in a pharmaceutically effective amount, and a method of making the compound having the structure of general formula (I) or a pharmaceutical acceptable salt, hydrate, or solvate thereof. The compound of formula (I) has multiple pharmacological functions such as the functions of activating opioid receptors and blocking dopamine D2 receptors, and has good physicochemical properties and oral bioavailability. General animal experiments show that such a compound has significant and long-lasting analgesic and calming effects and can be used to treat pain and other mental illnesses.

Use and preparation method of berberine compounds

Growing community of inventors

Irvine, CA, United States of America

Lien Wang