Shire Human Genetic Therapies, Inc.

Lieh Yoon Low

Michael F Concino

Angela Norton

Muthuraman Meiyappan

Bettina Strack-Logue

Bohong Zhang

Dianna Lundberg

Kevin Holmes

Andrea Iskenderian

Alla Romashko

Hicham Naimy

Omar L Francone

Tracy Dowie

Lin Guey

Bruce Tangarone

Matthew Traylor

Lenore Von Krusenstiern

Angela W Norton

A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.

Mannose-6-phosphate bearing peptides fused to lysosomal enzymes

A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.

Lipoprotein lipase for treatment of hypertriglyceridemic-related conditions including acute pancreatitis

Growing community of inventors

Lexington, MA, United States of America

Lieh Yoon Low