Wuhan University

Hubei Bio-pharmaceutical Industrial Technological Institute Inc.

Humanwell Healthcare (group) Co., Ltd.

Medshine Discovery Inc.

Wuhan Humanwell Innovative Drug Research and Development Center Limited Company

Humanwell Healthcare Co., Ltd.

Lie Li

Yigang He

Liulu He

Chenyuan Wang

Shuhui Chen

Yong Wang

Yong Xu

Lu Huang

Cailin Wang

Xuehai Wang

Ronghua Tu

Wenjie Sun

Hailiang Chen

Jie Shen

Chuankun Wang

Charles Z Ding

Lei Wang

Zheng Wang

Cong Wang

Hui Liu

Weidong Li

Bolun Du

Yingying Zhao

Yang YuE

Biao Deng

Jimeng Wang

Zhe Liu

Hui Zhang

Jiajun Duan

Zhaozhong Ding

Xuejun Zhang

Ming Xiang

Zhibo Zhang

Xiaoxin Wu

Xiaoyan Liu

Xiao Wang

Yang Yue

Zhaorong Zeng

Xiaohua Ding

Weiwei Zhang

Hongna Sun

Yonggang Wei

Dabing Ye

Yang Zang

Gang Li

The disclosure discloses a single-ended fault positioning method and system for a HVDC power transmission line based on a hybrid deep network. The method comprises the following: collecting rectification side bus output voltage and current signals of a HVDC power transmission system under different fault types, fault distances and transition resistances as an original data set; eliminating electromagnetic coupling of the bipolar direct-current line by using phase-mode transformation, extracting IMF components of fault voltage and current signals under different fault scenes by using variational mode decomposition, and calculating TEO of the IMF components to obtain a fault data set after feature engineering; normalizing the fault data set, and dividing the fault data set into a training set and a test set; and successively inputting the training set and the test set into a hybrid network of a convolutional neural network and a long short-term memory network for training and testing.

Single-ended fault positioning method and system for high-voltage direct-current transmission line of hybrid network

Provided is a new compound capable of effectively inhibiting ATX. The compound is represented by formula I, or the compound is a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula I. In formula (I), Rand Rare independently selected from —H or —CH, provided that: Rand Rare not —H at the same time or are not —CHat the same time.

Pyrrolopyrimidine derivative and use thereof

A method and a system for comprehensively evaluating reliability of a multi-chip parallel IGBT module are provided. The method includes: establishing a gate-emitter voltage reliability model of the multi-chip parallel IGBT module, performing a chip fatigue failure test, and selecting a gate-emitter voltage as a failure characteristic quantity; establishing a transconductance reliability model of the multi-chip parallel IGBT module, performing a bonding wire shedding failure test, and selecting a transmission characteristic curve of the module as a failure characteristic quantity; using a Pearson correlation coefficient to characterize a degree of health of the IGBT module, and respectively calculating degrees of health PPMCCand PPMCCin different degrees of chip fatigue and bonding wire shedding failure states; and comprehensively evaluating the reliability of the multi-chip parallel IGBT module according to PPMCCand PPMCC.

Method and system for comprehensively evaluating reliability of multi-chip parallel IGBT module

A method and system for predicting an insulated gate bipolar transistor (IGBT) lifetime based on compound failure mode coupling are provided. First, a simultaneous failure probability model of a bonding wire and a solder layer is calculated. Next, expectancy of the simultaneous failure probability model is calculated and recorded as a lifetime under a coupling effect. A coupling function relation is established. A lifetime of the solder layer and a lifetime of the bonding wire are predicted. An IGBT lifetime prediction model not taking the coupling effect into account is established. An IGBT lifetime prediction model taking the coupling effect into account is established. In the disclosure, the lifetime of the IGBT module under the coupling effect of the solder layer and the bonding wire may be accurately predicted.

Method and system for predicting insulated gate bipolar transistor lifetime based on compound failure mode coupling

A reliability evaluation method and system for a microgrid inverter IGBT based on segmented long short-term memory (LSTM) is disclosed, including steps as follows. An electrothermal coupling model is constructed to obtain real-time junction temperature data. The original LSTM algorithm is improved to obtain a segmented LSTM prediction network for the aging characteristics of the IGBT. The monitoring value of the IGBT aging parameter is used to perform segmented LSTM prediction to obtain the predicted aging process, and the threshold values of different aging stages are categorized. An aging correction is performed on the aging parameter of the electrothermal coupling model to ensure the accuracy of the junction temperature data. Rainflow-counting algorithm is used to calculate real-time thermal stress load distribution of the IGBT. The fatigue damage theory and the Lesit life prediction model are combined to calculate the real-time cumulative damage and predicted life of the IGBT.

Reliability evaluation method and system of microgrid inverter IGBT based on segmented LSTM

A wind power prediction method and system for optimizing a deep Transformer network by whale optimization algorithm are disclosed. The sequence data of wind power and related influence factors are taken as sample data which is divided into a training set and a test set, where the data is trained and predicted by a Transformer network model established according to values of the initialized hyper-parameters, and an average absolute error of wind power prediction is taken as a fitness value of each whale group. A local optimal position is determined according to the initial fitness value of individual whale group, and the current optimal position is updated by utilizing whale group optimization, and the best prediction effect is obtained by comparing the local optimal solution with the global optimal solution. An optimal hyper-parameter combination is obtained after multiple iterations of the whale optimization algorithm, and the wind power is predicted.

Wind power prediction method and system for optimizing deep transformer network

A serial IGBT voltage equalization method and system based on an auxiliary voltage source is disclosed. The method includes the following steps. (1) Detect a port dynamic voltage of each serial IGBT. (2) Perform dynamic overvoltage diagnosis respectively on the port dynamic voltage of each IGBT. (3) Supply emergency high level signal to the gate of the IGBT when there is dynamic overvoltage. (4) Stop supplying emergency high level signal to the gate of the IGBT, supply a constant voltage at the gate of the IGBT through the auxiliary voltage source. The invention provides a constant voltage through the auxiliary voltage source, prolongs the off time of the faulty IGBT, and turns off other IGBTs simultaneously, thereby achieving the purpose of serial IGBT voltage equalization.

Serial IGBT voltage equalization method and system based on auxiliary voltage source

The invention discloses a method and a system for correction of the junction temperatures of an IGBT module in a photovoltaic inverter. The method includes: constructing an electrothermal coupling model of an IGBT model based on a photovoltaic inverter topology, a light radiation intensity, and an ambient temperature; selecting an IGBT collector-emitter on-state voltage drop as an aging parameter and designing an on-state voltage drop sampling circuit to ensure measurement accuracy; constructing an aging database for IGBT modules in different aging stages based on large current and small current injection methods; comparing a junction temperature value output by the electrothermal coupling model with the calibrated junction temperature value and calibrating an aging process coefficient of an electrothermal coupling model correction formula; comparing an IGBT aging monitoring value with the aging threshold to determine the aging process and selecting a corresponding aging process coefficient to ensure accuracy of junction temperature data.

Method and system for online correction of junction temperatures of IGBT in photovoltaic inverter considering aging process

The disclosure discloses a multi-time-scale reliability evaluation method of a wind power IGBT considering fatigue damage and a system thereof. Lifetime information of a power device is comprehensively extracted by using multiple time scales. An electro-thermal coupling model of an IGBT module is established to obtain a junction temperature data. A steady-state junction temperature database of the IGBT in different aging states is established. Based on a SCADA monitoring data, the junction temperature data is outputted in real-time through the electro-thermal coupling model and a real-time thermal stress cycle number is calculated in a short-term time-scale profile, and a wind speed probability distribution curve is obtained in a long-term time-scale profile. A maximum thermal stress cycle number that the IGBT can withstand in different aging stages is obtained in advance and a cumulative damage degree and an estimated lifetime of the IGBT of the wind power converter are calculated.

Multi-time-scale reliability evaluation method of wind power IGBT considering fatigue damage and system thereof

A method and a system for power equipment diagnosis based on windowed feature and Hilbert visualization are provided, which belong to the field of power equipment fault diagnosis. The method includes: obtaining an original data set of monitoring data containing power equipment fault features; introducing windowed feature calculation considering logarithmic constraints to process data to obtain a feature sequence; using Hilbert visualization method for further processing to obtain a Hilbert image data set used to train and verify a convolutional neural network; and finally directly inputting newly obtained test sample data after windowed feature calculation and Hilbert visualization processing into the trained network for fault diagnosis and location. The disclosure uses windowed feature calculation and Hilbert visualization to process the monitoring data of a power equipment to fully extract fault features and effectively improve diagnostic accuracy, and uses the convolutional neural network for diagnosis to improve the intelligence of diagnosis.

Method and system for power equipment diagnosis based on windowed feature and Hilbert visualization

The disclosure discloses an IGBT module reliability evaluation method and device based on bonding wire degradation, which belong to the field of IGBT reliability evaluation. The realization of the method includes: obtaining a relationship between a IGBT chip conduction voltage drop Uand an operating current Ialong with a chip junction temperature T; for an IGBT module under test, obtaining the conduction voltage drop Uof the IGBT chip through the operating current Iand the chip junction temperature T; obtaining an external conduction voltage drop Uof the IGBT module by using a voltmeter; performing subtraction to obtain a voltage drop at a junction of a IGBT chip and a bonding wire, and combining the operating current to obtain a resistance at the junction; determining that the IGBT module has failed when the resistance at the junction increases to 5% of an equivalent impedance of the IGBT module.

IGBT module reliability evaluation method and device based on bonding wire degradation

Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof. The 4H-pyrazolo[1,5-alpha]benzimidazole compound has the structure of Compound 2. 

Salt type and crystal type of 4h-pyrazolo [1, 5-alpha] benzimidazole compound and preparation method and intermediate thereof

Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1,5-alpha]benzimidazole compound and a preparation method and intermediate thereof. The 4H-pyrazolo[1,5-alpha]benzimidazole compound is represented by formula I: 

Salt type and crystal type of 4H-pyrazolo [1, 5-alpha] benzimidazole compound and preparation method and intermediate thereof

Disclosed is a series of analogs of 4H-pyrazolo[1,5-&#x3b1;]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.

Analogues of 4H-pyrazolo[1,5-a] benzimidazole compound as PARP inhibitors

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Hubei, China

Lie Li