Atomic Energy Council-institute of Nuclear Energy Research

Institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

Atomic Energy Council

Lie-Hang Shen

Chia-Chieh Chen

Wuu-Jyh Lin

Wen-Song Hwang

Te-Wei Lee

Kuan-Yin Chen

Ying-Kai Fu

Ming-Chao Kuo

Zei-Tsan Tsai

Shyh-Yi Chyi

Bin Lin

Kung-Tien Liu

Yi-Chih Hsia

Haw-Jan Chen

Mei-Hsiu Liao

Yean-Chang Chen

Hsueh-Hsuan Liu

Meng-Chou Lee

Cheng-Fang Hsu

Mei-Hui Wang

Wen-Sheng Huang

Show-Wen Liu

Shui-Tein Chen

Cheng-Hsien Lin

Tsai-Yueh Luo

Tsyh-Lang Lin

Ko-Shao Chen

Shiang-Rong Chang

Shui-Cheng Lee

Gann Ting

Chia-Jung Chang

Te-Hsing Wu

Tian-Fu Huang

Nini-Chen Tsai

Yu-Chin Tseng

Ming-Der Yu

Wei-Lian Chen

Chang-Mau Shing

Kung-Tsung Wang

Yi-Chun Yeh

Mei-Chih Wu

Yuen-Han Yeh

Tai-Sheng Lin

Chang-Yung Su

Hang-Hsing Yang

Kuo-Hsing Ma

Lee-Chung Men

Shih-Woei Yeh

Ming-Yu Chao

Chia-jung Chang

An-Shoei Yang

Wei-Kang Chou

Wei-His Chen

Ying-Kai c/o Atomic Energy Council Fu

The present invention increases a number of target reaction containers from one into many. Coordinated with increased reaction times, total reaction volume is increased. By modifying an affinitive column of an automatic synthesis system, a production in a single batch is increased. The products obtained can be conformed to quality check specifications with cost saved.

Method of improving purity and yield of chemical product in automatic radioactive medicine synthesis system

The present invention is related to a direct solid sample analytical technology for determining a content and a uniformity thereof in a lyophilized kit of a sulfur-containing chelator with a stable complex capacity for radiotechnetium (Tc-99m) and radiorhenium (Re-186, Re-188). An economical, stable and easily accessible coal standard is used herein as a contrast substance to construct a sulfur calibration curve, followed by obtaining the sulfur content and the uniformity thereof in the solid lyophilized sample by interpolating the foregoing result into the sulfur calibration curve. Then, the weight content percent is converted to get the content and the uniformity of the chelator in the lyophilized kit. The quality control of active pharmaceutical ingredients (API) in the lyophilized kit during key production processes and clinical applications is thus assured.

Direct solid sample analytical technology for determining a content and a uniformity thereof in a lyophilized kit of a sulfur-containing chelator with a stable complex capacity for radiotechnetium (Tc-99M) and radiorhenium (Re-186, Re-188)

A method of single photon emission computed tomography (SPECT) using dual-isotopes of [Tc]TRODAT-1 and [I]ADAM is provided. Through SPECT, anomalies in dopamine and serotonin system are diagnosed with their photos in one examination. Thus, cost and labor for two examinations are saved and uses of SPECT are reduced.

Method of nuclear medical photography using dual-isotopes

An analytical technique for determining the structures of serotonin transporter (SERT) imaging agent [I] ADAM and its precursor, SnADAM by using a high-performance liquid chromatography tandem mass spectrometer (LC-MS/MS) is provided. An analytical technique for determining the purity of SnADAM by using a high-performance liquid chromatograph (HPLC) is also provided.

[object Object]

The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.

Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof

The present invention is to invent a novel method for testing the radiochemical purity of Tc-99m-TRODAT-1 through a high performance liquid chromatography on a widely available C-18 column.

Method for testing radiochemical purity of Tc-99m-TRODAT-1

A compound containing carboxylate ester and N2S2 ligand bi-functional groups and a manufacturing method thereof are disclosed. The S in the N2S2 ligand of the compound containing carboxylate ester and N2S2 ligand bi-functional groups includes a protective group so as to avoid to be oxidized and easy storage. In a complex reaction, the protective group is automatically released As to the active carboxylate ester, it is for reacting with compounds having amino groups such as amines, amino acids, peptides, or protein etc while the N2S2 ligand is for bonding with technetium or rhenium so as to form neutral complex. The compound containing carboxylate ester and N2S2 ligand bi-functional groups is applied to radiopharmaceuticals such as contrast agents for tissues and target agents.

Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof

Through a low-dose irradiation, a seaweed's growth becomes fast and its production is improved as well. By doing so, a material for biomass energy is provided.

Method of hormesis for seaweed through irradiation

A biomedical material is prepared through a plasma method. The material is a film containing titanium oxide onto polymer sheet. The film is hydrophilic, bacterial inactivated and biocompatible. The present invention can be applied to artificial guiding tube and wound dressing material.

Plasma method for TiOx biomedical material onto polymer sheet

A wild seaweed, like sea lettuce, is picked and germ cells are released from the seaweed. The germ cells then obtain adherence and are sprouted into youngs of the seaweed so that the seaweed can be cultivated artificially and productively and can be supplied as a material for biomass energy.

Method for cultivating seaweed having adherence

This invention is a novel synthesis of BCA-peptides (BCA: bifunctional chelating agents). In this method, the starting material--Fmoc-Thr(ol)-Terephthal-Acetal-Amide Resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)-Terephtha l-Acetal-Amide Resin was obtained. This compound reacted with iodine to give disulfide-containing peptide resin of ##STR1## Cleavage of the peptide from the resin was achieved by TFA. The cleavaged peptide was protected by the reaction of octreotide with di-t-butyldicarbonate. BCA was coupled to the selectively protected octreotide. This product was obtained by reaction of protected BCA-peptides with TFA. The final product was labeled by radioisotope .sup.111 InCl.sub.3 for tumor imaging radiopharmaceuticals.

Method for synthesis of bifunctional chelating agents-peptides

Novel tumor imaging agents in which the dimercaptosuccinic acid was dissolved in phosphate buffer and labelled with radioisotope gallium. The product of gallium dimercaptosuccinate has been characterized by a variety of experiments including serum stability, biodistribution and imaging experiment. As the results, the compound of gallium dimercaptosuccinate has been confirmed as a novel radiopharmaceutical for tumor imaging agent.

Gallium dimercaptosuccinate as a novel tumor imaging agent

Growing community of inventors

Taoyuan County, Taiwan

Lie-Hang Shen