Academia Sinica

Lie-Fen Shyur

Ning-Sun Yang

Sheng-Yang Wang

Wen-Chin Yang

Yi-Ping Chen

Shu-Lin Chang

Ya-Wen Cheng

Chia-Chung Hou

Jyh-Horng Wu

Chi-Chang Huang

Jia-Hua Feng

Yi-Ming Chiang

Maria Karmella Apaya

Wen-Wan Chao

Kuo-Hsiung Lee

Jui-Lin Chen

Lee-Tian Chang

Shu-Hua Lee

Yuhsin Chen

Chih-An Hsu

Jo-Yu Chen

Wai-Leng Lee

Yu-Ting Cheng

Jing-Ying Huang

Tuan-Nan Wen

Pei-Fen Su

Chin-Jin Li

Kyoko Nakagawa-Goto

Pei-Ling Kang

Wei-Chun Liu

Show-Jane Sun

Meng-Ting Chang

Chih-Ting Chang

Wai Leng Lee

This disclosure is directed to essential oils, and methods of their use in treating skin conditions. The skin conditions include those involving HRASmutant keratinocyte activity, wherein the essential oil inhibits said activity to treat and/or prevent skin cancer. Particularly, the present invention denotes to and composition for inhibiting and prevent skin carcinogenesis or BRAF inhibitor, a type of anti-cancer drug induced cutaneous side effect.

Mint essential oils inhibitmutant keratinocyte activity and prevent skin carcinogenesis

A method for treating breast cancer and/or treating breast cancer metastasis in a subject in need of such treatment including administering to said subject an effective amount ofextract and optionally a pharmaceutically acceptable carrier or excipient.

Use ofextract in the treatment of breast cancer

The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of:subsp.(Asteraceae) (GD),(C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), andS. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.

Galactolipids-enriched plant extracts and the uses thereof

A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

Sesquiterpene derivatives and their use in inflammation or cancer treatment

Described herein is a fusion polypeptide that contains (a) a first segment containing a1,3-1,4-&#x3b2;-D-glucanase (Fs&#x3b2;-glucanase) or a fragment thereof; (b) a second segment containing a first1,3-&#x3b2;-D-glucanase (TmLam) or a fragment thereof; and (c) an optional third segment containing a second1,3-&#x3b2;-D-glucanase (TmLam) or a fragment thereof; wherein the fusion polypeptide has a glucanase activity. Also described are a nucleic acid molecule encoding the fusion polypeptide and a method of using the polypeptide.

Dual-functional hybrid glucanases

Methods for preventing and/or reducing side effects of an anti-cancer agent in a subject in need thereof are disclosed. The method comprises administering to the subject, who is under an anti-cancer agent treatment, a composition comprising a therapeutically effective amount of isolated deoxyelephantopin and/or an analog thereof; and a pharmaceutically acceptable carrier.

Use of deoxyelephantopin (DET) and analogues thereof for reducing side effects of an anti-cancer agent

Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of deoxyelephantopin or an analogue thereof; and a pharmaceutically acceptable carrier. Methods of inhibiting proliferation, migration and/or metastasis of melanoma cells in a subject in need thereof are also disclosed. Also disclosed are methods for reducing side effects of an anti-cancer agent in a subject in need thereof.

Use of deoxyelephantopin (DET) and analogues thereof for treatment of melanoma

Novel laccases fromsp. WR1 andsp. and uses thereof.

Fungal laccases and uses thereof

Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.

Treatment of cancer and inflammatory disorder

A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein Ris H, alkyl, aryl, or cyclyl; Ris pyranose; Ris H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.

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Methods useful, for example, in identifying plant compositions that have immunomodulatory activity. Also disclosed is an Asteraceae plant immunomodulatory composition useful for increasing an immune response, e.g., IFN &#x3b3; or IL-2 transcription.

Immunomodulatory compositions

Cancer and inflammatory disorder treatment

A truncated 1,3-1,4-&#x3b2;-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.

Truncated 1,3-1,4-&#x3b2;-D-glucanase

A method for enhancing proliferation of bone marrow cells or spleen cells with an alcohol-insoluble extract of aplant tuber obtained by stepwise treatment of an aqueous extract ofplant tuber with aqueous-alcohol solvents.

Growing community of inventors

Taipei, Taiwan

Lie-Fen Shyur