Almirall Prodesfarma S.a.

Laboratorios Almirall, S.a.

Lidia Soca Pueyo

Carles Puig Duran

Paul Robert Eastwood

Silvia Fonquerna Pou

Bernat Vidal Juan

Lluis Miquel Pages Santacana

Maria Isabel Crespo Crespo

Juan Miguel Jimenez Mayorga

Christina Esteve Trias

The present disclosure relates to a compound of formula (I) wherein: or a pharmaceutically acceptable salt thereof, or a N-oxide thereof. The present disclosure also relates to a method for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the Aadenosine receptor.

Pyrazine derivatives useful as adenosine receptor antagonists

The invention relates to indolyl piperidinyl derivatives of formula (I) wherein: Arepresents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group; Arepresents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group; Wrepresents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; Wrepresents a 3&#x2013;10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups; Rrepresents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group; and Rrepresents a carboxyl group; and pharmaceutically acceptable salts thereof; to processes for their preparation; to pharmaceutical compositions containing them; and to their medical use as antihistaminic and antiallergic agents.

Indolylpiperidine derivatives as antihistaminic and antiallergic agents

2-phenylpyran-4-one derivatives

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Barcelona, Spain

Lidia Soca Pueyo