Bristol-myers Squibb Compnay

Lidet A Negash

Saleem Ahmad

John T Hynes

Hao Zhang

Shung C Wu

Sean Chen

Peter T W Cheng

Shiwei Tao

Kandhasamy Sarkunam

Ling Li

Peter TW Cheng

Disclosed are compounds of Formulas (I) or (II) or a salt thereof, wherein X, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

Tricyclic heteroaryl compounds useful as IRAK4 inhibitors

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein R, R, and Rare defined herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is CRor N; Y is CRor N; provided that only one of X and Y is N; (R1) is: or; wherein R, R, R, R, R, and Rare define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. 

Thienopyridines and benzothiophenes useful as IRAK4 inhibitors

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

Dihydropyridinone MGAT2 inhibitors

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

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Plainsboro, NJ, United States of America

Lidet A Negash