Eureka Therapeutics, Inc.

Lianxing Liu

Hong Liu

Yiyang Xu

Lucas Horan

Pengbo Zhang

Hongruo Yun

Zhiyuan Yang

Javier Morales

Shan Li

Binnaz K Staley

Guangyan Xiong

Yixiang Xu

Jun Cui

Xiaomei Ge

Shaohua Xu

The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.

Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof

The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.

Constructs trageting CD22 and uses thereof

The present application provides chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule. Also provided are methods of making and using these constructs.

Chimeric antibody/T-cell receptor constructs and uses thereof

Growing community of inventors

San Francisco, CA, United States of America

Lianxing Liu