Abbott Cardiovascular Systems, Inc.

Liangxuan Zhang

Stephen D Pacetti

Mikael Trollsas

Florencia Lim

John Joseph Stankus

Shubhayu Basu

Florian Ludwig

Evgenia Mandrusov

John L Toner

Jinping Wan

Hong Ma

Ed Berger

This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor.

Method of treating malignant solid tumors using transcatheter arterial chemoembolization (TACE)

Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.

Multiple growth factor compositions, methods of fabrication, and methods of treatment

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Palo Alto, CA, United States of America

Liangxuan Zhang