Shaanxi University of Science and Technology

Shaanxi Panlong Pharmaceutical Co., Ltd.

Xi'an Taikomed Pharmaceutical Technology Co., Ltd.

Shaanxi Panlong Pharmaceutical Group Limited by Share Ltd.

Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd.

Liang Xin

Jingyi Li

Chengyuan Liang

Han Li

Dan Yang

Bin Tian

Qianqian Zhao

Liang Qi

Wenbo Yao

Yongbo Wang

Lei Tian

Gennian Mao

Dezhu Zhang

Xiaolin Xie

Kangxiong Wu

Ruina Bian

Guaiping Qiao

Yanjun Li

Shaojun Zhang

Juan Li

Nan Hui

Jie Zhang

Juan Xia

Zhao Ma

Xuhua Zhou

Xiuding Yang

Yuqing Zhao

Chunyang Shi

Xingke Ju

Xuechuan Wang

Yonghong Tang

Taotao Qiang

Jingwen Xu

Minghui Chang

Huafeng Qi

Qiao Zeng

Nan Qin

Jian Zha

Zhenfeng Shi

Yuting Liu

Qingbo Zhao

Min Li

Catherine J Lee

Maggie Lewis

Sundian Liu

Yu Wang

Shunjun Ding

Jianguo Meng

Zhong Meng

Zhuanmei Yuan

Jiayun Zhang

Wenjing Yang

Cong Du

Qi Lu

Jialin Li

Boyang Li

The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.

3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and preparation method and use thereof

A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R, R, R, Rand Rare independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections

Aseed extract includes the following components by weight based on a total weight of theseed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing theseed extract is disclosed. A composition for treating antibiotic-resistant infections that includes theseed extract is also disclosed.

seed extract composition and its application in antibiotic-resistant infections

A method of preparing a hydroxytyrosol sturgeon skin gelatin film with antioxidant activity anddetection ability includes: (1) mixing a neutral red indicator solution and distilled water at room temperature to obtain a mixture solution, and adding 1 mol/L NaHCOsolution to the mixture solution until discoloration to obtain an alkaline solution; (2) adding an amount of the alkaline solution obtained in step (1) to a mixture of Sturgeon skin gelatin and distilled water to obtain an alkaline gelatin solution; (3) adding hydroxytyrosol and glycerin and propylene glycol to the alkaline gelatin solution to obtain a hydroxytyrosol gelatin solution, and heating the hydroxytyrosol gelatin solution at 40-70&#xb0; C.; (4) ultrasonicating the hydroxytyrosol gelatin solution from step (3), placing the hydroxytyrol gelatin solution evenly on a clean plexiglass plate, drying the hydroxytyrol gelatin solution on an ultra-clean worktable to obtain the hydroxytyrosol sturgeon skin gelatin film.

Hydroxytyrosol sturgeon skin gelatin film with antioxidant activity anddetection ability and a method of preparing the same

Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R, R, Rand Rare independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; Ris a hydrogen or halogen; and Ris hydrogen, C1-4 alkane or C1-4 cycloalkane.

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

Pleuromulin lipoic acid ester with antibacterial activity and a method of preparing the same

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromulin 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ester with antibacterial activity and a method of preparing the same

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

Pleuromutilin (phenylthio)acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

Pleuromutilin (E)-4-(1-imidazoylmethyl)cinnamic acid ester with anti-drug resistant bacteria activity and a method of preparing the same

A compound with anti-drug resistant bacteria activity having the formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromutilin 2-[(diphenylmethyl)thio] acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same

A compound with anti-drug resistant bacteria activity having the following formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromutilin salicylic acid ester with antibacterial activity and a method of preparing the same

A compound with antibacterial activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

Pleuromutilin ursodeoxycholic acid ester with antibacterial activity and a method of preparing the same

Pleuromulin tretinoin ester with antibacterial activity and a method of preparing the same

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Xi'an, China

Liang Xin