Pilot Polymer Technologies, Inc.

Amgen Inc.

Atrp Solutions, Inc.

Liang Huang

Patrick McCarthy

Yuanxi Liao

Sheng Cui

Patrick Mccarthy

Sian Jones

Ying Chen

Austin G Smith

Krishnakumar Ranganathan

Richard Crockett

Kevin Crossley

Asher Lower

Jeroen Bezemer

Jason S Tedrow

Robert Ronald Milburn

Philipp C Roosen

John T Colyer

Matthew G Beaver

Alan H Cherney

Oliver Thiel

Donald Bogus

Kyle D Baucom

Gabrielle St-pierre

Rahul P Sangodkar

Michael A Lovette

Ari Ericson

Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

Ring closing synthesis of macrocyclic MCL-1 inhibitor intermediates

Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and Rare described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.

Synthesis of vinylic protected alcohol intermediates

The present invention relates to a composition comprising at least one sulfonated surfactant composition and one or more multi-arm star macromolecules having a core and a plurality of polymeric arms, and methods of preparing and using the same. In one aspect of the invention, this composition is capable of increasing the viscosity, and/or temperature-stability to an aqueous system.

Combination of a sulfonated surfactant composition and star macromolecules

A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

Method for preparing AMG 416 (etelcalcetide)

The present invention relates to multi-arm salt-tolerant star macromolecules, and methods of preparing and using the same. In one aspect of the invention, a salt-tolerant star macromolecule is capable of providing salt-tolerance to an aqueous composition.

Salt-tolerant star macromolecules

The present invention relates to multi-arm star macromolecules which are used as thickening agents or rheology modifiers, including use in hydraulic fracturing fluid compositions. In one aspect of the invention, a star macromolecule is capable of thickening via a dual mechanism comprising (1) self-assembly of the hydrophobic polymerized segments of the star macromolecules via hydrophobic interactions or associations, and (2) association, reaction, or combination of the hydroxyl-containing polymerized segments of one or more of the star macromolecules.

Dual-mechanism thickening agents for hydraulic fracturing fluids

The present invention relates to multi-arm surfactant-system thickening star macromolecules, and methods of preparing and using the same. In one aspect of the invention, a surfactant-system thickening star macromolecule is capable of providing surfactant-compatibility, increase the viscosity of a surfactant-containing system, and/or temperature-stability to an aqueous composition.

Surfactant-compatible star macromolecules

A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).

Method for preparing AMG 416

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Liang Huang