Chinese Academy of Medical Sciences

Bayer Aktiengesellschaft

Chinese Academy of Sciences

Taisho Pharmaceutical Co., Ltd.

Liang Huang

Geng-tao Liu

Shoudong Huo

Ming-he Yang

Xuhui Zhou

Yan-rong Chen

Taikun Shi

Jiaru Zou

Shengqiang Mu

Guoxu Shu

Yan Li

Katsuo Hatayama

Kensei Yoshikawa

Ulrich Benz

Tatsuhiko Sano

Jiangyun Zhang

Jian Cao

Iwao Arai

Juntian Zhang

Er-chang Rao

Ping Yu

Shohei Higuchi

Jin Zhou

Zhenghui Gao

Zhangqing Sun

Yen-rong Chen

Shiming Chen

Fuxing Han

Mingran Liu

Kemei Wu

Wenchao Su

A method for determining hydraulic fractures in the near-wellbore region, comprising the following steps: constructing a model with hydraulic fractures, a wellbore, and a formation as main components, and discretizing the model using non-uniform grid technology. This data subset is inverted using the time-lapse full-waveform inversion (TL-FWI) algorithm to achieve high-precision reconstruction of the hydraulic fractures and to obtain key attributes such as fracture-wellbore connectivity, extent of fracture propagation, and fracture geometry.

Quantitative evaluation method for hydraulic fractures in near-wellbore region

A media Parameter-modified method for realizing an adaptive expression of an arbitrary discontinuous surface, comprising the following steps: importing an initial forward model, importing anisotropic parameters; and setting a space step and a time step according to the initial forward model parameters; and then starting a stepped discretization of a free surface of the initial forward model; and using a corrected constitutive relationship to correct a first level parameter of the initial forward model; and bringing the corrected constitutive relationship into a displacement stress equation, and the influence of the free surface can be introduced in the case of the anisotropic media after series of operation. The present disclosure can make an accurate numerical simulation of a wave field near the discontinuous surface, and the accurate numerical simulation will contribute to the extraction and analysis of information from the seismic data.

Media parameter-modified method for realizing an adaptive expression of an arbitrary discontinuous surface

An irregular seismic data collection method is based on forward modeling. The method includes: fully collecting geological information of a work area to build a geological model, determining arrangement parameters of receiver points and shot points for regular high-density collection and irregular sparse collection, performing irregular optimization design on positions of the shot points based on forward modeling, performing irregular optimization design on positions of the receiver points based on forward modeling, and outputting a preferred irregular sparse observation system. Compared with the existing technologies, an arrangement scheme of shot points and receiver points in the present invention, including the irregular sparse observation system, implements irregular optimization design of the shot points and the receiver points based on a forward modeling technology by using a greedy strategy, so that the designed irregular observation system can suppress to the greatest extent spatial aliasing caused by irregular sparse collection.

Forward simulation-based irregular seismic data acquisition method

A dip angle-steering median filtering method based on a niche differential evolution algorithm, comprising the following steps: dividing a data to be processed into a series of overlapping time-space windows; obtaining an event energy curve in a time-space window and obtaining an event position according to a local maximum value of the event energy curve; obtaining event dip angles and coherence values of the event dip angles through the niche differential evolution algorithm at the event position; filtering the event dip angles according to the event dip angles and the coherence values of the event dip angles; and performing a median filtering sequentially along a filtering dip angle. The disclosure can simultaneously obtain all dip angles of intersecting events and a true three-dimensional feature enable the present disclosure to obtain a better filtering effect.

Dip angle-steering median filtering method based on a niche differential evolution algorithm

The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.

Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use

A process for the preparation of compound of the formula ##STR1## in which R.sup.1 --represents ##STR2## and R.sup.2 --represents hydrogen, fluorine, chlorine or bromine. Comprising cyclizing compounds of the formula ##STR3## and, in a further step, either a) reducing stereo-specifically to give compounds of the formula in which R.sup.1 represents ##STR4## or b), to give compounds of the formula in which R.sup.1 represents ##STR5## or by c) forming compounds of the formula ##STR6## followed by stereoselective reduction to give compounds in which R.sup.1 represents ##STR7##

Process for the preparation of clausenamide and neoclausenamide, and

Processes for the preparation of compounds of the formula ##STR1## in which R and R.sup.1 are identical or different and represent hydrogen or halogen, in the racemic form or in the form of its pure enantiomers by cyclicizing compounds of the formula ##STR2## with 2,6-lutidine or by cyclicizing compounds of the formula ##STR3## with diethyl azodicarboxylate. Compounds where R is halogen are new and are useful as cerebral therapeutics, nootropics or in the reduction of increased glutamine pyruvate transaminase in serum.

Dehydrocycloclausenamide, its preparation and use in treating cerebral

N-substituted amide derivative represented by the formula ##STR1## wherein A is --CH(OH)-- or --C(.dbd.O)--, R.sup.1 is a hydrogen atom or an lkyl group having 1 to 3 carbon atoms, and R.sup.2 is an alkyl group having 1 to 6 carbon atoms, are disclosed. These compounds are useful for prevention and therapy for liver diseases.

N-substituted amide derivatives useful for treating liver diseases

A pharmacologically active .epsilon.-valerolactam has been isolated from the leaves of Clausena lansium. This compound and its derivatives have the formula ##STR1## where R is hydrogen or a C.sub.1 -C.sub.18 -acyl group. It has been found that these compounds are useful in the treatment of hypoxia and as antiamonestics.

Pharmacologically active .epsilon.-valerolactams

Purified Clausenamide of the formula ##STR1## is obtained by extraction of leaves of Clausena lansium followed by purification, Reduction products, ethers, etc. can be produced. The compounds are effective in treating hypoxia and amnesia.

Delta-butyrolactams, thereof, processes for the preparation thereof and

Compounds of the general formula ##STR1## wherein R.sub.1 represents hydrogen, an acyl group having 1 to 18 carbon atoms or both R.sub.1 together the group ##STR2## R.sub.2 represents hydrogen or a methyl group, have been isolated in small amounts from the leaves of Clausena lansium. The new compounds are to be used for the production of compositions for the use of the treatment of acute and chronical viral hepatitis, liver intoxication, hypoxia or amnesia.

2,3-dihydroxy-3-phenyl-N-(2-phenyl-ethyl)-propionic acid amides

A pharmacologically active phenyl-substituted bicyclic lactam has been isolated from the leaves of Clausena lansium. This compound and its derivatives have the formula ##STR1## Where R is hydrogen of a C.sub.1 -C.sub.18 -acyl group. It has been found that these compounds are useful in the treatment of hypoxia and as antiamnestics.

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Beijing, China

Liang Huang