Pfizer Corporation

Liang H Huang

Walter P Cullen

Walter D Celmer

Riichiro Shibakawa

Junsuke Tone

John R Oscarson

Takushi Kaneko

Charles E Moppett

Mark A Guadliana

Mark T Jefferson

Paul C Watts

Nakao Kojima

Yasuhiro Kojima

Yuji Yamauchi

Hiroshi Maeda

Satoshi Nishiyama

Taisuke Inagaki

Gloria J Kostek

Keiji Kaneda

Koenraad A Dekker

Junsuki Tone

Kozo Inoue

Thomas T Dabrah

H James Harwood, Jr

Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C -C ) alkyl or CH (CH ) CO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H antagonist, colloidal bismuth subcitrate and other antibiotics.

Compounds for treating gastroduodenal diseases

Spirolaxine derivatives for treating gastrobuodenal diseases

Process for preparing spirolaxine and spirolaxine methyl ether

Quinolone compounds for the treatment of disorders caused by

Streptomyces braegensis strain and its cultivation in a process for

The culture ATCC 74256 and its mutants are capable of producing zaragozic acid A and other squalene synthase inhibitors. The compound of formula I herein may be prepared from culture ATCC 74256 and is useful in the treatment of fungal infections, and inhibition of squalene synthase, and protein farnesyltransferase.

Inhibitor of squalene synthase

Antibiotics CP-54,715 and CP-54,716, identified by their analytical characteristics, are produced by fermentation of a new microbial species Catenuloplanes jaonicus in a new genus Catenuloplanes and are active against gram-positive and anaerobic infections.

Antibiotics produced by a new microbe, Catenuloplanes japonicus

A new subspecies of Streptomyces nigellus Prokop, designated Streptomyces nigellus Prokop subsp. africanus Huang subsp. nov. ATCC 31496, when propagated under aerobic conditions in aqueous nutrient media, produces a mixture of antibiotics. One of these antibiotics is the known macrolide antibiotic cirramycin A; the ansamycin antibiotic is an analogue of protostreptovaricin and the structure has been established as 21-hydroxy, 25-demethyl, 25-methylthioprotostreptovaricin I.

Ansamycin antibiotic

Process for producing new ansamycin antibiotic

A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.

Antibiotics produced by species of Nocardia

A new species of Nocardiopsis, designated Nocardiopsis atra Huang sp. nov. ATCC 31511, when aerobically propagated in an aqueous nutrient medium, produces nocardicin A in good yield.

Process for producing nocardicin A

A new polycyclic ether antibiotic produced by a strain of Actinomadura verrucosospora under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

New polycyclic ether antibiotic

A species of Actinoplanes, designated Actinoplanes deccanensis Parenti, Pagani and Beretta subsp. salmoneus Huang subsp. nov., ATCC 31355, when subjected to submerged aerobic fermentation, produces a new antibiotic complex. Methods for the recovery and purification of the antibiotic complex and some of the individual antibiotic components are described.

Antibiotics produced by species of actinoplanes

A new polycyclic ether antibiotic produced by a strain of Streptomyces hygroscopicus under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

Polycyclic ether antibiotic produced by a strain of streptomyces

A new species of Nocardia, designated Nocardia argentinensis Huang sp. nov., when subjected to aerobic submerged fermentation, produces a mixture of new antibiotics. Methods for the recovery and purification of these antibiotics are described and some of their antimicrobial properties are outlined.

Antibiotics produced by new species of nocardia

Growing community of inventors

East Lyme, CT, United States of America

Liang H Huang