United Therapeutics Corporation

Bone Care International, Inc.

Other

Mannkind Corporation

The United States of America As Represented by the Secretary of

United Therapeutics Corporaiton

Oncquest, Inc.

Horst, Ronald L.

Koszewski, Nicholas J.

Reinhardt, Timothy A.

Liang Guo

Hitesh Batra

Robert M Moriarty

Raju A Penmasta

Charles W Bishop

Joyce C Knutson

Glenville Jones

Stephen Strugnell

Lei Zhao

Ronald L Horst

Timothy A Reinhardt

Nicholas J Koszewski

Sanjay K Singhal

Munagala Rao

Kenneth R Phares

Patrick Poisson

James P Staszewski

Sri Harsha Tummala

Elizabeth Ann Harris

Ken Phares

Rajendra G Mehta

Adam Marc Silverstein

Susovan Jana

Sanjay K Singh-Al

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Prodrugs of treprostinil

Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Treprostinil prodrugs

Provided are treprostinil derivatives with a reduced ability to form undesired impurities in a pharmaceutical formulation, such as a dry powder formulation, further containing a carboxyl group containing inactive ingredient, such as fumaryl diketopiperazine.

Treprostinil derivatives and their use in pharmaceutical compositions

Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.

Synthesis of esuberaprost prodrugs

Stable treprostinil prodrugs

Prodrugs of treprosiinil

An herbal distillation device includes a herb chamber with perforated holes for holding herbs and a closed heated boiling chamber with openings at the side for a steam outlet. The herbal distillation device further includes an electric air-cooled condensation chamber which connects to the boiling chamber.

Automatic distiller and infuser

A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.

Process for making beraprost

A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.

Process of making prostacyclin compounds with linker thiol and pegylated forms

A compound of formula I:wherein R1 is hydrogen, R2 is &#x2014;CH, R3 is &#x2014;CH, and R4 is hydrogen, useful in cancer prevention and therapy.

1&#x3b1;-Hydroxyvitamin D5, its synthesis and use in cancer prevention

An improved method is described for making 9-deoxy-PGF -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF -type compounds.

Process for stereoselective synthesis of prostacyclin derivatives

Growing community of inventors

Vienna, VA, United States of America

Liang Guo