Medarex Inc.

E. R. Squibb Sons, Inc.

Liang Chen

Haichun Huang

Sanjeev Gangwar

Vincent Guerlavais

Bilal Sufi

Zhi-Hong Li

Nils Lonberg

Qian Zhang

Josephine M Cardarelli

David B Passmore

Chin Pan

Sharon Elaine Boyd

Kilian Horgan

Killian Horgan

Sharon Boyd

Sanjeev Ganwar

David John King

The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical linkers with single amino acids and conjugates thereof

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical linkers and cleavable substrates and conjugates thereof

The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical linkers and conjugates thereof

The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.

Cytotoxic compounds and conjugates

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Discovery Bay, CA, United States of America

Liang Chen