Alza Corporation

Other

Encinal Pharmaceutical Investments, LLC

Liang-Chang Dong

Patrick S-l Wong

Patrick S L Wong

David E Edgren

Steven Espinal

Padmaja Shivanand

Felix T Theeuwes

Atul D Ayer

Jae Hyun Kim

Michael A DesJardin

Vincent Joseph Ferrari

Gurdish K Bhatti

Francisco Jao

Phyllis I Gardner

Shu W Li

Si-Hong Yum

Jason J Wan

Shaoling Li

Crystal Pollock

Sung Joo Hwang

Keru O Shafi

Ted Smith

Wei-guo Dai

Dong Ho Lee

Tae-Hong Choi

A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200&#xb0; C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.

Dosage form comprising liquid formulation

The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.

Expandable osmotic composition and coating suspension

A dosage form is disclosed comprising a drug formulation that self-emulsifies in the drug formulation.

A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.

Pharmaceutical coating composition and method of use

A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.

Osmotic dosage form composed of an extruded polymer tube form

A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of time up to 24 hours.

Dosage form comprising therapeutic formulation

The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

Prolonged release active agent dosage form adapted for gastric retention

A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.

Polymeric compositions are disclosed comprising a poly(caprolactone), a poly(alkylene oxide), a poly(oxyethylenated fatty acid ester), or a poly(oxyethylenated fatty acid), or a poly(oxyethylene-co-oxypropylene).

Growing community of inventors

Sunnyvale, CA, United States of America

Liang-Chang Dong