Inalco S.p.a.

Basf Se Corporation

Inalco S.a.s. Di Giovanni Cipolletti & C.

Liana Salsini

Giovanni Cipolletti

Gessica Laudati

Michael Puhl

Debora Bartalucci

Giancarlo Tamerlani

Marco Manoni

Ilaria Lombardi

Jacopo Chini

Andrea Danesi

Silvia Rapaccini

This invention describes new hydrated and anhydrous polymorphs of 2'-O-fucosyllactose (2&#x2032;FL): Polymorph A 2&#x2032;FL-3/2HO, Polymorph B 2TL-5/2 HO and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.

Hydrated and anhydrous polymorphs of 2'-O- fucosyllactose and their production methods

Hydrated and anhydrous polymorphs of 2'-O-fucosyllactose and their production methods

This invention describes new hydrated and anhydrous polymorphs of 2'-0-ficosyllactose (2&#x2032;FL): Polymorph A 2&#x2032;FL-3/2HO, Polymorph B 2TL-5/2HO and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.

This invention describes new hydrated and anhydrous polymorphs of 2'-0-fucosyllactose (2&#x2032;FL): Polymorph A 2&#x2032;FL-3/2HO, Polymorph B 2TL-5/2 HO and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature. 

The present invention relates to a process of synthesis of &#x3b1;-sialyl oligosaccharides and in particular of 6'-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.

6'-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides

The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N&#x2014; acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.

Polysaccharide derivatives with high antithrombotic activity in plasma

Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing nucleotides of the L series having antiviral activity 

Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives

The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I):useful in the synthesis of nucleotides.

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Seravezza, Italy

Liana Salsini